Artigo Produção Nacional Revisado por pares

Can We Predict Which Patients will Experience Resolution of Detrusor Overactivity after Transurethral Resection of the Prostate?

2015; Lippincott Williams & Wilkins; Volume: 193; Issue: 6 Linguagem: Inglês

10.1016/j.juro.2014.12.095

ISSN

1527-3792

Autores

Alberto A. Antunes, Alexandre Iscaife, Sabrina T. Reis, Aline Albertini, Marco Antônio Prado Nunes, Antonio Marmo Lucón, William Carlos Nahas, Miguel Srougi,

Tópico(s)

Prostate Cancer Diagnosis and Treatment

Resumo

No AccessJournal of UrologyAdult Urology1 Jun 2015Can We Predict Which Patients will Experience Resolution of Detrusor Overactivity after Transurethral Resection of the Prostate? Alberto Azoubel Antunes, Alexandre Iscaife, Sabrina Thalita Reis, Aline Albertini, Marco Antonio Nunes, Antonio Marmo Lucon, William Carlos Nahas, and Miguel Srougi Alberto Azoubel AntunesAlberto Azoubel Antunes More articles by this author , Alexandre IscaifeAlexandre Iscaife More articles by this author , Sabrina Thalita ReisSabrina Thalita Reis More articles by this author , Aline AlbertiniAline Albertini More articles by this author , Marco Antonio NunesMarco Antonio Nunes More articles by this author , Antonio Marmo LuconAntonio Marmo Lucon More articles by this author , William Carlos NahasWilliam Carlos Nahas More articles by this author , and Miguel SrougiMiguel Srougi More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.12.095AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We determined which clinical and urodynamic variables may be related to persistent detrusor overactivity after transurethral resection of the prostate. Materials and Methods: We studied 46 patients with bladder outlet obstruction due to benign prostatic hyperplasia who were treated with transurethral prostate resection from 2011 to 2012. All patients underwent urodynamic analysis preoperatively and 12 months postoperatively. Clinical and urodynamic variables in the preoperative period were correlated with the resolution of detrusor overactivity postoperatively. Results: Patients with detrusor overactivity in the preoperative period were older (65.2 vs 61.1 years, p = 0.041) and had a higher I-PSS (International Prostate Symptom Score) (25.2 vs 19, p = 0.014) and higher maximum flow rate (8.6 vs 6.6 ml per second, p = 0.039). Patients with persistent detrusor overactivity were statistically older than those with resolution (69 vs 63 years, p = 0.043). Detrusor overactivity persisted in 63.6% of patients with maximum cystometric capacity less than 250 ml compared to 20% of those with greater than 250 ml (p = 0.024). When analyzing urodynamic variables together, we found a 66.7% chance of persistent detrusor overactivity in patients with maximum cystometric capacity less than 250 ml and detrusor overactivity amplitude greater than 40 cm H2O (p = 0.041). When these characteristics were associated with early detrusor overactivity, the chance of persistent detrusor overactivity was 83.3% (p = 0.013). Conclusions: Advanced patient age together with low maximum cystometric capacity, and early and high detrusor overactivity amplitude are the most important predictors of persistent detrusor overactivity after relief of bladder outlet obstruction. References 1 : BPH: epidemiology and comorbidities. Am J Manag Care2006; 12: S122. Google Scholar 2 : Quality-of-life impact of lower urinary tract symptom severity: results from the Health Professionals Follow-up Study. Urology2002; 59: 245. Google Scholar 3 : Economic costs of benign prostatic hyperplasia in the private sector. J Urol2005; 173: 1309. 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Google Scholar 15 : Distribution and changes with age of calcitonin gene-related peptide- and substance P-immunoreactive nerves of the rat urinary bladder and lumbosacral sensory neurons. Eur J Morphol2002; 40: 293. Google Scholar 16 : Comparison of the effects of oestrogen deficiency and old age on primary bladder afferent activity and voiding behaviour in the ageing female rat. BJU Int2010; 108: E10. Google Scholar 17 : Functional and morphological modifications of the urinary bladder in aging female rats. Am J Physiol Regul Integr Comp Physiol2000; 278: R964. Google Scholar 18 : Detrusor expulsive strength is preserved, but responsiveness to bladder filling and urinary sensitivity is diminished in the aging mouse. Am J Physiol Regul Integr Comp Physiol2012; 302: 577. Google Scholar 19 : Persistent detrusor overactivity after transurethral resection of the prostate is associated with reduced perfusion of the urinary bladder. BJU Int2007; 99: 831. Google Scholar © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 6June 2015Page: 2028-2032Supplementary Materials Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.Keywordsoveractiveprostatic hyperplasiaurinary bladderage factorsurinary bladder neck obstructiontransurethral resection of prostateMetricsAuthor Information Alberto Azoubel Antunes More articles by this author Alexandre Iscaife More articles by this author Sabrina Thalita Reis More articles by this author Aline Albertini More articles by this author Marco Antonio Nunes More articles by this author Antonio Marmo Lucon More articles by this author William Carlos Nahas More articles by this author Miguel Srougi More articles by this author Expand All Advertisement PDF downloadLoading ...

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