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STEVENS-JOHNSON DISEASE

1948; American Medical Association; Volume: 48; Issue: 3 Linguagem: Inglês

10.1001/archotol.1948.00690040373007

1538-361X

L. K. ELFMAN,

Pediatric health and respiratory diseases

IN 1922 Stevens and Johnson 1 reported a new symptom complex, occurring in 2 of their patients. Since then, additional cases have been reported, so that this symptom complex now rests on a fairly firm foundation of accurate clinical observations. The syndrome is variously reported as Stevens-Johnson disease or syndrome or as atypical erythema exudativum multiforme (Hebra) with involvement of the eyes and mucous membranes. The syndrome 2 consists of the following symptoms: Stomatitis Ophthalmia Cutaneous eruption analogous to erythema exudativum multiforme (Hebra) Fever It is important for the rhinologist to become acquainted with this syndrome, 3 as he may be the first to see a patient with early symptoms of a badly infected mouth and pharynx which resemble those of severe Vincent's angina or stomatitis caused by a blood dyscrasia. The cutaneous lesions, the ophthalmia and certain complications, such as pneumonia, vulvovaginitis and balanitis, may follow. Relapses are not uncommon. Hebra 4 in 1866 first