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Role of EBER and BARF1 in nasopharyngeal carcinoma (NPC) tumorigenesis

2011; Elsevier BV; Volume: 22; Issue: 2 Linguagem: Inglês

10.1016/j.semcancer.2011.12.007

1096-3650

Kenzo Takada,

Cancer-related molecular mechanisms research

Epstein-Barr virus (EBV)-encoded small RNA (EBER) is the most abundant EBV viral transcript and is used as a target molecule to detect EBV-infected cells in tissues by in situ hybridization. EBER is expected to form double-stranded RNA-like structures. The results of the present study show that EBER contributes to oncogenesis by modulating innate immunity in patients with NPC and Burkett's lymphoma. BARF1 is a homolog of the human proto-oncogene c-fms and is expressed as a latent gene in NPC. Reconstitution of NPC-type EBV infection using NPC-derived cell lines shows that BARF1 contributes to the tumorigenicity of NPC cells.