Factors related to and consequences of weight loss in patients with stomach cancer. The norwegian multicenter experience
1991; Wiley; Volume: 67; Issue: 3 Linguagem: Inglês
10.1002/1097-0142(19910201)67
ISSN1097-0142
AutoresTrond Haugstvedt, Asgaut Viste, Geir Egil Eide, Odd Söreide,
Tópico(s)Pancreatic and Hepatic Oncology Research
ResumoOf 1165 patients with stomach cancer included in a national, prospective multicenter study with 51 surgical units participating, information about weight loss before diagnosis was available for 855 patients (73%). Median weight loss was 5 kg; 259 patients (31%) experienced no weight loss. By logistic regression analysis the authors found that weight loss increased with age and advancing stages of disease (TNM Stage I–IV), with decreasing Karnofsky index, in Lauren's diffuse versus intestinal tumor type, and with tumors located at the cardia/esophagus. Increasing weight loss reduced the resectability rate significantly, but no association between weight loss and postoperative complication rate was found. The odds ratio for postoperative mortality was 2.5 to 1 for the weight loss group 5 to 10 kg versus 0 kg. In conclusion, weight loss reflects a less favorable tumor status. Weight loss did not increase postoperative morbidity but did lead to a higher death rate after surgery.
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