Benzologs of allopurinol: Synthesis of pyrazolo [4,3-g] and [3,4-f] quinazolinones
1980; Elsevier BV; Volume: 21; Issue: 32 Linguagem: Inglês
10.1016/s0040-4039(00)77398-9
ISSN1873-3581
AutoresEckehard Cuny, Frieder W. Lichtenthaler, Alfred Moser,
Tópico(s)HIV/AIDS drug development and treatment
ResumoConvenient syntheses of pyrazolo [4,3-g]quinazolin-5 (6H) -one (3), its xanthine oxidase metabolite 4 and the [3,4-f] analog 5 have been developed, involving anellation of the pyrimidine ring onto aminoindazolcarboxylic acids 9 and 18, or attachment of the pyrazol portion onto quinazolinone 22 via intramolecular azo coupling.
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