The IL-33/ST2 axis augments effector T-cell responses during acute GVHD
2015; Elsevier BV; Volume: 125; Issue: 20 Linguagem: Inglês
10.1182/blood-2014-10-606830
ISSN1528-0020
AutoresDawn K. Reichenbach, Vincent Schwarze, Benjamin M. Matta, Victor Tkachev, Elisabeth Lieberknecht, Quan Liu, Brent H. Koehn, Dietmar Pfeifer, Patricia A. Taylor, Gabriele Prinz, Heide Dierbach, Natalie Stickel, Yvonne Beck, Max Warncke, Tobias Junt, Annette Schmitt‐Graeff, Susumu Nakae, Marie Follo, Tobias Wertheimer, Lukas Schwab, Jason Devlin, Simon C. Watkins, Justus Duyster, James L.M. Ferrara, Hēth Turnquist, Robert Zeiser, Bruce R. Blazar,
Tópico(s)Eosinophilic Esophagitis
ResumoKey Points IL-33 and ST2 expression are increased post-conditioning and with GVHD, resulting in increased T-cell activation via the IL-33/ST2 axis. Infusion of ST2-Fc protein exploits sST2’s function as a negative regulator of acute GVHD inhibiting pro-inflammatory cytokines.
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