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EXAMINATION OF THE ALKALOIDS OF LUPINUS DIGITATUS FORSK. FOR HEPATOTOXIC EFFECTS IN THE RAT

1963; Wiley; Volume: 41; Issue: 2 Linguagem: Inglês

10.1038/icb.1963.12

1440-1711

JE Peterson,

Chemical synthesis and alkaloids

SUMMARY The alkaloids d‐ epi lupinine, d‐ epi lupinine‐ N ‐oxide and LV‐1 from Lupinus digitatus Forsk., the West Australian blue lupin, were administered to rats by intraperitoneal injection three times weekly at dose rates of 0·1 and 0·33 LD 50 (based on acute toxicity) for periods of 6 to 25 weeks. Particular examination was made for evidence of hepatotoxic effects. None of the alkaloids produced liver damage in rats on a normal diet or on a diet restricted in its content of lipotropic factors. These findings are discussed in relation to lupinosis of sheep.