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Sulfonamide-containing polymers: a new class of pH-sensitive polymers and gels

2001; Wiley; Volume: 172; Issue: 1 Linguagem: Inglês

10.1002/1521-3900(200107)172

1521-3900

Seong Il Kang, Kun Na, You Han Bae,

Polymer Surface Interaction Studies

Macromolecular SymposiaVolume 172, Issue 1 p. 149-156 Article Sulfonamide-containing polymers: a new class of pH-sensitive polymers and gels Seong Il Kang, Seong Il Kang Center for Biomaterials and Biotechnology, Department of Materials Science and Engineering, Kwangju Institute of Science and Technology, 1 Oryong-dong, Puk-gu, Kwangju, 500-712, KoreaSearch for more papers by this authorKun Na, Kun Na Center for Biomaterials and Biotechnology, Department of Materials Science and Engineering, Kwangju Institute of Science and Technology, 1 Oryong-dong, Puk-gu, Kwangju, 500-712, KoreaSearch for more papers by this authorYou Han Bae, You Han Bae Center for Biomaterials and Biotechnology, Department of Materials Science and Engineering, Kwangju Institute of Science and Technology, 1 Oryong-dong, Puk-gu, Kwangju, 500-712, KoreaSearch for more papers by this author Seong Il Kang, Seong Il Kang Center for Biomaterials and Biotechnology, Department of Materials Science and Engineering, Kwangju Institute of Science and Technology, 1 Oryong-dong, Puk-gu, Kwangju, 500-712, KoreaSearch for more papers by this authorKun Na, Kun Na Center for Biomaterials and Biotechnology, Department of Materials Science and Engineering, Kwangju Institute of Science and Technology, 1 Oryong-dong, Puk-gu, Kwangju, 500-712, KoreaSearch for more papers by this authorYou Han Bae, You Han Bae Center for Biomaterials and Biotechnology, Department of Materials Science and Engineering, Kwangju Institute of Science and Technology, 1 Oryong-dong, Puk-gu, Kwangju, 500-712, KoreaSearch for more papers by this author First published: 30 August 2001 https://doi.org/10.1002/1521-3900(200107)172:1 3.0.CO;2-GCitations: 28AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract New pH-responsive polymers and hydrogel nanoparticles were synthesized, which bear either sulfapyridine or sulfamethoxypyridazine. The linear copolymers in water showed soluble/insoluble transition, while the hydrogel nanoparticles in aqueous solutions experienced association/dissociation transition in a narrow pH range. Their pH sensitivity was confirmed by the change in turbidity or particle size as a function of pH. The ionization of SO2NH group in sulfonamides is responsible for aggregation of the polymers or hydrogel nanoparticles. The transition pH is determined by the amount of SO2NH groups in the copolymers or on the hydrogel nanoparticle surface; at an optimum composition, the transitions occur near physiological pH. These systems may present a potential for various biomedical and bioengineering fields, such as pulsatile drug delivery, targeting, embolization, sensors, and bioseparation. Citing Literature Volume172, Issue1July 2001Pages 149-156 RelatedInformation