RATES OF DECLINE DISTINGUISH ALZHEIMER'S DISEASE AND MILD COGNITIVE IMPAIRMENT RELATIVE TO NORMAL AGING: INTEGRATING COGNITION AND BRAIN FUNCTION
2007; Imperial College Press; Volume: 06; Issue: 01 Linguagem: Inglês
10.1142/s0219635207001374
ISSN1757-448X
AutoresBelinda J. Liddell, Robert Paul, Martijn Arns, Norman Gordon, Matthew Kukla, DONALD L. ROWE, Nicholas R. Cooper, Jonson Moyle, Leanne M. Williams,
Tópico(s)Diet and metabolism studies
ResumoJournal of Integrative NeuroscienceVol. 06, No. 01, pp. 141-174 (2007) Research ReportsNo AccessRATES OF DECLINE DISTINGUISH ALZHEIMER'S DISEASE AND MILD COGNITIVE IMPAIRMENT RELATIVE TO NORMAL AGING: INTEGRATING COGNITION AND BRAIN FUNCTIONBELINDA J. LIDDELL, ROBERT H. PAUL, MARTIJN ARNS, NORMAN GORDON, MATTHEW KUKLA, DONALD ROWE, NICK COOPER, JONSON MOYLE, and LEANNE M. WILLIAMSBELINDA J. LIDDELL The Brain Resource International Database and the Brain Resource Company, NSW 2007, Australia The Brain Dynamics Center, Westmead Millennium Institute, Westmead Hospital, and Western Clinical School, University of Sydney, NSW 2145, AustraliaCorresponding author.., ROBERT H. PAULUniversity of Missouri — St. Louis, Behavioral Neuroscience, St. Louis, USA, MARTIJN ARNSThe Brain Resource Company B.V./Brainquiry B.V. Nijmegen, The Netherlands, NORMAN GORDONDepartment of Neurology, Brown University of School of Medicine, Providence, Rhode Island, USA, MATTHEW KUKLABrain Resource Company, Providence, Rhode Island, USA, DONALD ROWEThe Brain Dynamics Center, Westmead Millennium Institute, Westmead Hospital, and Western Clinical School, University of Sydney, NSW 2145, AustraliaPsychological Medicine, Western Clinical School, University of Sydney, NSW 2145, Australia, NICK COOPERThe Brain Resource International Database and the Brain Resource Company, NSW 2007, Australia, JONSON MOYLEThe Brain Resource International Database and the Brain Resource Company, NSW 2007, Australia, and LEANNE M. WILLIAMSThe Brain Dynamics Center, Westmead Millennium Institute, Westmead Hospital, and Western Clinical School, University of Sydney, NSW 2145, AustraliaPsychological Medicine, Western Clinical School, University of Sydney, NSW 2145, Australiahttps://doi.org/10.1142/S0219635207001374Cited by:31 PreviousNext AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsRecommend to Library ShareShare onFacebookTwitterLinked InRedditEmail AbstractAims: Increasing age is the strongest risk factor for Alzheimer's disease (AD). Yet, departure from normal age-related decline for established markers of AD including memory, cognitive decline and brain function deficits, has not been quantified.Methods: We examined the cross-sectional estimates of the "rate of decline" in cognitive performance and psychophysiological measures of brain function over age in AD, preclinical (subjective memory complaint-SMC, Mild Cognitive Impairment-MCI) and healthy groups. Correlations between memory performance and indices of brain function were also conducted.Results: The rate of cognitive decline increased between groups: AD showed advanced decline, and SMC/MCI groups represented intermediate stages of decline relative to normal aging expectations. In AD, advanced EEG alterations (excessive slow-wave/reduced fast-wave EEG, decreased working memory P450 component) were observed over age, which were coupled with memory decline. By contrast, MCI group showed less severe cognitive changes but specific decreases in the working memory N300 component and slow-wave (delta) EEG, associated with decline in memory.Discussion and Integrative Significance: While the cognitive data suggests a continuum of deterioration associated with increasing symptom severity across groups, integration with brain function measures points to possible distinct compensatory strategies in MCI and AD groups. 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Snyder21 December 2007 | Alzheimer's & Dementia, Vol. 4, No. 1S1INTEGRATING OBJECTIVE GENE-BRAIN-BEHAVIOR MARKERS OF PSYCHIATRIC DISORDERSEVIAN GORDON, BELINDA J. LIDDELL, KERRI J. BROWN, RICHARD BRYANT, C. RICHARD CLARK, PRITHA DAS, CAROL DOBSON-STONE, ERIN FALCONER, KIM FELMINGHAM, GARY FLYNN, JUSTINE M. GATT, ANTHONY HARRIS, DANIEL F. HERMENS, PATRICK J. HOPKINSON, ANDREW H. KEMP, STACEY A. KUAN, ILLARIO LAZZARO, JONSON MOYLE, ROBERT H. PAUL, CHRIS J. RENNIE, PETER SCHOFIELD, THOMAS WHITFORD, and LEANNE M. WILLIAMS21 November 2011 | Journal of Integrative Neuroscience, Vol. 06, No. 01 Recommended Vol. 06, No. 01 Metrics History Received 8 November 2006 Accepted 19 February 2007 KeywordsAlzheimer's disease (AD)Mild Cognitive Impairment (MCI)Subjective Memory Complaint (SMC)normal agingcognitionEEGworking memoryintegrative neurosciencePDF download
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