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Intestinal Absorption and Blood Clearance of l -Histidine-Related Compounds after Ingestion of Anserine in Humans and Comparison to Anserine-Containing Diets

2009; American Chemical Society; Volume: 57; Issue: 5 Linguagem: Inglês

10.1021/jf8030875

1520-5118

Daiki Kubomura, Yoshiharu Matahira, Ayano Masui, Hideki Matsuda,

Biochemical Analysis and Sensing Techniques

Anserine is a bioactive dipeptide found in muscles and brains of vertebrates, but little is known about the kinetics of its absorption into blood and the clearance after the ingestion of anserine or anserine-containing diets. This study investigated time-dependent changes in the concentrations of l-histidine-related compounds from deproteinized blood. The concentration of anserine peaked and then decreased to zero, whereas the concentration of π-methylhistidine gradually increased, at which point anserine was not detected. Thus, ingested anserine is absorbed intact in human blood and is hydrolyzed to π-methylhistidine and β-alanine by serum and tissue carnosinases. Moreover, the crossover study suggests that there was no significant difference in absorption under curves of anserine between anserine alone and anserine-containing diet, whereas there was significant difference in the peak concentration of anserine. This is the first study to demonstrate intestinal absorption and blood clearance of anserine.