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Contribution of the pentose cycle to glucose metabolism in muscle

1965; Elsevier BV; Volume: 111; Issue: 3 Linguagem: Inglês

10.1016/0003-9861(65)90236-5

1096-0384

Marie R. Green, Bernard R. Landau,

Parkinson's Disease Mechanisms and Treatments

Glucose-2-C14 has been incubated with abdominal muscle, diaphragm, and slices of heart from baby and adult mice. Glucose from glycogen and ribose from nucleotides have been degraded. From the C14-distribution in the glucose, the pentose cycle contribution to over-all glucose metabolism in abdominal muscle and diaphragm could not definitely be established, but it does not exceed 2%; in heart it appears to be somewhat higher. Distributions of C14 in glucose from glycogen and ribose are in accord with incorporation of C14 via the oxidative and nonoxidative portions of the cycle. While incorporation via the oxidative portion can be attributed to synthesis, incorporation via the nonoxidative portion may occur via exchange reactions rather than synthesis.