Portal de Periódicos da CAPES

Prevalence of Lactose Malabsorption in Mexican Children: Importance of Measuring Methane in Expired Air

2013; Elsevier BV; Volume: 44; Issue: 4 Linguagem: Inglês

10.1016/j.arcmed.2013.04.005

1873-5487

Segundo Morán, Aline Mina, Ximena Duque, Salome Anaya, Uritzimar San-Martin, Patricia Yañez, Gustavo Arturo Rodríguez-Leal,

Diet, Metabolism, and Disease

To compare the prevalence of lactose malabsorption (LM) in children by analyzing hydrogen content in expired air vs. the inclusion of methane excretion.A total of 138 children (4-17 years old) attending different boarding schools in Mexico were included in this study. To measure H₂ and CH₄ in expired air, breath samples were collected before administering whole milk (240 mL for 4- to 6-year-old children and 360 mL for 7- to 17-year-old children) and at 60, 120, 180, and 240 min afterward. A coprological examination was also carried out.Methane production prevalence was 47.8% (29.7% of the children produced methane and hydrogen, whereas 18.1% produced methane only). When measuring only exhaled hydrogen in expired air (H₂ ≥20 ppm), prevalence of LM was 31%; however, when methane concentration was considered (H₂ + (CH₄ x 2)) ≥18 ppm, prevalence increased significantly to 44%. Among children with LM, 51.6% presented intestinal parasites.Methane should be measured in exhaled air to improve diagnosis of LM in populations with a high prevalence of methane production.