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Sleep Deprivation Decreases Ventilatory Response to CO2 But Not Load Compensation

1983; Elsevier BV; Volume: 84; Issue: 6 Linguagem: Inglês

10.1378/chest.84.6.695

1931-3543

Philip L. Schiffman, Marie C. Trontell, Martin F. Mazar, Norman H. Edelman,

Chronic Obstructive Pulmonary Disease (COPD) Research

Because sleep is known to reduce ventilatory drive, and sleep deprivation is a common accompaniment to ventilatory failure, we tested ventilatory response to carbon dioxide (ΔV1/ΔPco2) and response to an inspiratory flow resistive load (change in ΔP100/ΔPco2 with load) after both a normal night of sleep and after 24 hours of sleep deprivation in 13 healthy volunteers. Sleep deprivation was associated with a significant decrease in ΔV1/ΔPco2 from 2.51 ±.36 to 2.09 ±.34 L/min/mm Hg (p<0.02). However, load compensation was preserved during sleep deprivation. Since many acutely-ill patients are sleep deprived, an associated reduction of ventilatory drive may play a role in progressive respiratory insufficiency. Because sleep is known to reduce ventilatory drive, and sleep deprivation is a common accompaniment to ventilatory failure, we tested ventilatory response to carbon dioxide (ΔV1/ΔPco2) and response to an inspiratory flow resistive load (change in ΔP100/ΔPco2 with load) after both a normal night of sleep and after 24 hours of sleep deprivation in 13 healthy volunteers. Sleep deprivation was associated with a significant decrease in ΔV1/ΔPco2 from 2.51 ±.36 to 2.09 ±.34 L/min/mm Hg (p<0.02). However, load compensation was preserved during sleep deprivation. Since many acutely-ill patients are sleep deprived, an associated reduction of ventilatory drive may play a role in progressive respiratory insufficiency.