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Dehydroepiandrosterone: An anti‐obesity and anti‐carcinogenic agent

1981; Routledge; Volume: 3; Issue: 1 Linguagem: Inglês

10.1080/01635588109513700

1532-7914

Arthur G. Schwartz, Gordon C. Hard, Laura L. Pashko, Magid Abou‐Gharbia, Daniel Swern,

Adipose Tissue and Metabolism

Long-term treatment of female C3H-Avy/A (obese) and C3H-A/A (non-obese) mice with dehydroepiandrosterone, an adrenal steroid found in subnormal levels in women predisposed to develop breast cancer, reduces weight gain without suppressing appetite and significantly inhibits the development of spontaneous breast cancer. This steroid also antagonizes the capacity of the tumor promoter, 12-0-tetradecanoyl-phorbol-13-acetate, to stimulate 3H-thymidine incorporation in mouse epidermis and in a cultured rat kidney epithelial cell line.