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Dendritic cells induce T cell proliferation to synthetic antigens under Ir gene control.

1980; Rockefeller University Press; Volume: 152; Issue: 6 Linguagem: Inglês

10.1084/jem.152.6.1817

1540-9538

Geoffrey H. Sunshine, David R. Katz, Marc Feldmann,

Immune Cell Function and Interaction

Dendritic cells prepared by a modification of the method of Steinman and Cohn are I-A+ and FcR-. They are extremely potent at activating not only allogeneic T cell proliferation but also antigen-specific syngeneic T cell proliferation. Dendritic cells from nonresponder strains are unable to present antigens to responder X nonresponder T cells, suggesting that they may be a site of Ir gene product expression.