Portal de Periódicos da CAPES

Nuclear localisation of glutathione S-transferase π is an evaluation factor for drug resistance in gynaecological cancers

2005; Elsevier BV; Volume: 17; Issue: 4 Linguagem: Inglês

10.1016/j.clon.2004.11.008

1433-2981

Yoko Soh, Satoshi Goto, Michio Kitajima, Shingo Moriyama, Kouhei Kotera, Takahiro Nakayama, Hideto Nakajima, Takahito Kondo, Tetsuya Ishimaru,

Genomics, phytochemicals, and oxidative stress

Nuclear glutathione S-transferase pi (GST7pi) has been reported to protect cancer cells against anticancer drugs. The aim of the present study was to evaluate the clinical significance of nuclear GSTpi in gynaecological cancer.We carried out an immunohistochemical analysis of GSTpi, and examined the correlation between nuclear GSTpi: expression and prognosis in 43 epithelial ovarian cancers. We compared expression levels before and after chemotherapy in uterine cervical cancers and endometrial cancers.The 5-year progression-free survival rate of the nuclear GSTpi-positive group was lower than that of the cytoplasmic GSTpi-positive group, and was significantly lower than that of the negative group (14.3% vs 34.8% vs 66.7%; P = 0.041). The expression of nuclear GSTpi was compared before and after chemotherapy in uterine cervical and endometrial cancers. In eight out of 12 cases (66.7%), the expression turned positive after the chemotherapy.We suggest that nuclear localisation of GSTpi is associated with drug resistance. The nuclear localisation of GSTpi in tumour cells is a useful prognosticator, and may contribute to the selection of anticancer drugs for gynaecological cancers.