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A HISTOLOGICAL AND IMMUNOLOGICAL STUDY OF THE EFFECT OF RABBIT ANTI-MOUSE LYMPHOCYTE SERUM IN BALB/c MICE

1969; Wolters Kluwer; Volume: 7; Issue: 5 Linguagem: Inglês

10.1097/00007890-196905000-00001

1534-6080

Carlo Baroni, John W. Kimball, Elsie N. Ward, R. D. WAGAR,

Immunotoxicology and immune responses

The effect of i.p. administration of antilymphocyte serum (ALS) has been studied in BALB/c mice. The serum was given at different times before, with, and/or after sheep red blood cells. The results indicate that: (1) ALS acts on circulating lymphocytes more rapidly than on those of lymph nodes; (2) ALS acts primarily on lymphocytes of the paracortical areas; (3) ALS depresses bone marrow lymphocytes and not myeloid cells; (4) ALS markedly depresses immune responses to sheep red blood cells only if given prior to the antigen; and (5) recovery of immunosuppression occurs with time. It appears from these observations that ALS affects primarily the thymus-derived cells located in the paracortical areas of lymph nodes and exerts its immunosuppressive effects via the antigen-sensitive cells.