A novel metabolite of oxycodone in the urine of rabbits.
1982; Pharmaceutical Society of Japan; Volume: 5; Issue: 2 Linguagem: Inglês
10.1248/bpb1978.5.134
ISSN1881-1353
AutoresTakashi Ishida, Kazuta Oguri, Hidetoshi Yoshimura,
Tópico(s)Pharmacogenetics and Drug Metabolism
ResumoIn addition to six metabolites of oxycodone which were reported previously, 7 beta-hydroxy-6 beta-oxycodol was further isolated as one of the major metabolites in rabbits. The structure of this novel metabolite was characterized by mass and nuclear magnetic resonance spectra. Such a metabolite possessing vicinal hydroxyl groups in aliphatic ring is very new in the metabolism of narcotic analgesics.
Referência(s)