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Growth rate analysis of lung metastases from histologically benign giant cell tumor of Bone

1987; Wiley; Volume: 59; Issue: 10 Linguagem: Inglês

10.1002/1097-0142(19870515)59

1097-0142

Eliezer Katz, Meir Nyska, Elimelech Okon, G. Zajicek, Gordon C. Robin,

Sarcoma Diagnosis and Treatment

CancerVolume 59, Issue 10 p. 1831-1836 ArticleFree Access Growth rate analysis of lung metastases from histologically benign giant cell tumor of Bone Eliezer Katz M.D., Corresponding Author Eliezer Katz M.D. Department of General Surgery, Hadassah University Hospital the Hebrew University-Hadassah Mediccal School, Jerusalem, IsraelDepartment of General surgery, Haddassah U niversity Hospital, Kiryat Hadassah, Ein Karem, P.O.B. 120000, 91120 Jerusalem, Israel===Search for more papers by this authorMeir Nyska M.D., Meir Nyska M.D. Department of Orthopedic Surgery, Hadassah University Hospital the Hebrew University-Hadassah Mediccal School, Jerusalem, IsraelSearch for more papers by this authorElimelech Okon M.D., Elimelech Okon M.D. Department of Pathology, the Hadassah University Hospital the Hebrew University-Hadassah Mediccal School, Jerusalem, IsraelSearch for more papers by this authorGershom Zajicek M.D., Gershom Zajicek M.D. H. H. Humphrey Center for Experimental Medicine and Cancer Research, the Hebrew University-Hadassah Mediccal School, Jerusalem, IsraelSearch for more papers by this authorGordon Robin F.R.C.S., Gordon Robin F.R.C.S. Department of Orthopedic Surgery, Hadassah University Hospital the Hebrew University-Hadassah Mediccal School, Jerusalem, IsraelSearch for more papers by this author Eliezer Katz M.D., Corresponding Author Eliezer Katz M.D. Department of General Surgery, Hadassah University Hospital the Hebrew University-Hadassah Mediccal School, Jerusalem, IsraelDepartment of General surgery, Haddassah U niversity Hospital, Kiryat Hadassah, Ein Karem, P.O.B. 120000, 91120 Jerusalem, Israel===Search for more papers by this authorMeir Nyska M.D., Meir Nyska M.D. Department of Orthopedic Surgery, Hadassah University Hospital the Hebrew University-Hadassah Mediccal School, Jerusalem, IsraelSearch for more papers by this authorElimelech Okon M.D., Elimelech Okon M.D. Department of Pathology, the Hadassah University Hospital the Hebrew University-Hadassah Mediccal School, Jerusalem, IsraelSearch for more papers by this authorGershom Zajicek M.D., Gershom Zajicek M.D. H. H. Humphrey Center for Experimental Medicine and Cancer Research, the Hebrew University-Hadassah Mediccal School, Jerusalem, IsraelSearch for more papers by this authorGordon Robin F.R.C.S., Gordon Robin F.R.C.S. Department of Orthopedic Surgery, Hadassah University Hospital the Hebrew University-Hadassah Mediccal School, Jerusalem, IsraelSearch for more papers by this author First published: 15 May 1987 https://doi.org/10.1002/1097-0142(19870515)59:10 3.0.CO;2-ACitations: 36AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract A growth rate analysis of lung metastaws of benign gaint cell tumor (GCT) Of Bone, Histologically Indistinguishable from the Primary benign tumor, is presented. The doubling time (DT) was 186 days in the first 13 months of growth, and 465 days in the last 4 months. These Dts are much longer than DT of lung metastases of any other tumors, and have a good correlation with a long survival time. Backward extrapolation showed that the lung metastases began to develop years before the primary tumor was diagnosed and treated. If this can be confirmed in a larger number of patients, it could be concluded that there will be no indication for amputation as a treatment for benign GCT whether or not lung metastases are present. The growth rate analysis supports the concept that these metastases might represent a benign process, and as such are a unique histologic and clinical phenomenon. References 1 Jaffe HL, Lichtenstein L, Portis RB. Giant cell tumor of bone: Its pathologic appearance, grading, supposed variants and treatment. Arch Pathol 1940; 30: 993–1031. 2 Rock MG, Douglas JP, Unni KK. Metastases from histologically benign giant cell tumor of bone. J Bone Joint Surg 1984; 66-A (2): 269–274. 3 Dahlin DC, Cupps RE, Johnson EW Jr. Giant-cell tumor: A study of 195 cases. Cancer 1970; 25: 1061–1070. 4 Sanerkin NG. Malignancy, aggressiveness, and recurrence in giant cell tumor of bone. Cancer 1980; 46: 1641–1649. 5 Huvos AG. Bone Tumor: Diagnosis, Treatment, Prognosis. Philadelphia: W. B. Saunders, 1979. 6 Narcimiento AG, Huvos AH, Mariove RC. Primary malignant giant cell tumor of bone: A study of eight cases and review of the literature. Cancer 1979; 44: 1393. 7 Mirra JM, Ulich T, Magidson J, Kaiser L, Eckardt J, Gold R. A case of probable benign pulmonary "metastases" or implants arising from a giant cell tumor of bone. Clin Orthoped Rel Res 1982; 162: 245–254. 8 Caballes RL. The mechanism of metastasis in the so-called "benign giant cell tumor of bone." Hum Pathol 1981; 12: 762–767. 9 Inoue H, Ishihara T, Ikeda T et al. Benign giant cell tumor of femur with bilateral multiple pulmonary metastases. J Thorac Cardiovasc Surg 1977; 74: 935–938. 10 Vanel D, Contezzo G, Rebibo G, Zafrani B, Masselot J. Benign giant-cell tumours of bone with pulmonary metastases and favourable prognosis. Skeletal Radiol 1983; 10: 221–226. 11 Eisenberg E, Krutchkoff DJ. Giant cell tumor of bone (letter to the editor). Hum Pathol 1982; 13: 86–87. 12 Brunton GF, Wheldon TE. Characteristic species dependent growth patterns of mammalian neoplasms. Cell Tissue Kinet 1978; 11: 161–175. 13 Charbit A, Malaise EP, Tubiana M. Relation between the pathological nature and the growth rate of human tumours. Eur J Cancer 1971; 7: 307–315. 14 Tubiana M. L. H. Gray Medical Lecture: Cell kinetics and radiation oncology. Radiat Oncol Biol Phys 1982; 8: 1471–1489. 15 Breur K. Growth rate and radiosensitivity of human tumours: I. Growth rate of human tumours. Eur J Cancer 1966; 2: 157–171. 16 Rambert P, Malaise E, Laugier A, Schlienger M, Tubiana M. Donnees sur la vitesse de croissance de tumeurs humaines. Bull Cancer 1968; 55: 323–342. 17 Trott KR, Heinze HG, Kiesel B, Kollmann G, Kummermehr J. Die wachstumsgeschwindigkeit von lungenmetastasen. Strahlentherapie 1979; 155: 748–753. 18 Collins VP, Leiffler RK, Tivey H. Observations on growth rates of human tumors. Am J Roentgenol 1956; 76: 988–1000. 19 Malaise EP, Chavaudra N, Charbit A, Tubiana M. Relationship between the growth rate of human metastases, survival and pathological type. Eur J Cancer 1974; 10: 451–459. 20 Breur K. The growth pattern during the life history of human solid tumors before and after therapy. Communication to the Conference on the Biological Behavior and Chronobiology in Tumours. Oslo, June 1976. 21 Cohen P. Het osteosarcoom van de lange pijnbeenderen (189 cases of osteosarcoma of the limb) (Thesis). Amsterdam, 1974. 22 Jeffrey GM, Price CHG, Sissons HA. The metastatic patterns of osteosarcoma. Br J Cancer 1975; 32: 87–107. 23 Jaffe HL. Giant cell tumour (osteoclastoma) of bone: Its pathologic delimitation and the inherent clinical implications. Ann R Coll Surg 1953; 13: 343–355. 24 Goldenberg RR, Campbell CJ, Bonfiglio M. Giant-cell tumor of bone: An analysis of 218 cases. J Bone Joint Surg 1970; 52-A: 619–663. 25 Dyke SC. Metastasis of the "benign" giant-cell tumour of bone (osteoclastoma). J Pathol Bacteriol 1931; 34: 259–263. 26 Huvos AG. "Benign" metastasis in giant cell tumor of bone: (Letter to the editor). Hum Pathol 1981; 12: 1151. 27 Szyfelbein WM, Schiller AL. Cytologic diagnosis of giant cell tumor of bone metastatic to lung: A case report. Acta Cytol 1979; 23: 460–464. 28 Stargaroter FL, Cooperman LR. Giant-cell tumor with multiple pulmonary metastases and long-term survival. Br J Radiol 1971; 44: 976–979. 29 Murphy WR, Ackerman LV. Benign and malignant giant-cell tumors of bone: A clinical-pathological evaluation of 31 cases. Cancer 1956; 9: 317–339. 30 Di Lorenzo N, Spallone A, Nolletti A, Nardi P. Giant cell tumors of the spine: A clinical study of six cases, with emphasis on the radiological features, treatment, and follow-up. Neurosurgery 1980; 6: 29–34. 31 Cohen DM, Dahlin DC, Maccarty CS. Vertebral giant-cell tumor and variants. Cancer 1964; 17: 461–472. 32 Lichtenstein L. Bone Tumors, ed. 2. St. Louis: CV Mosby, 1959. 33 Maccarty CS, Dahlin DC, Doyle JB Jr, Lipscomb PR, Pugh DG. Aneurysmal bone cysts of the neural axis. J Neurosurg 1961; 18: 671–677. Citing Literature Volume59, Issue1015 May 1987Pages 1831-1836 ReferencesRelatedInformation