STRESS AND SYMPTOMATOLOGY IN PATIENTS WITH INTERSTITIAL CYSTITIS: A LABORATORY STRESS MODEL
2000; Lippincott Williams & Wilkins; Volume: 164; Issue: 4 Linguagem: Inglês
10.1016/s0022-5347(05)67152-2
ISSN1527-3792
AutoresSusan K. Lutgendorf, Karl J. Kreder, Nan Rothrock, Timothy L. Ratliff, Bridget Zimmerman,
Tópico(s)Kidney Stones and Urolithiasis Treatments
ResumoNo AccessJournal of UrologyFemale Urology1 Oct 2000STRESS AND SYMPTOMATOLOGY IN PATIENTS WITH INTERSTITIAL CYSTITIS: A LABORATORY STRESS MODEL SUSAN K. LUTGENDORF, KARL J. KREDER, NAN E. ROTHROCK, TIMOTHY L. RATLIFF, and BRIDGET ZIMMERMAN SUSAN K. LUTGENDORFSUSAN K. LUTGENDORF , KARL J. KREDERKARL J. KREDER , NAN E. ROTHROCKNAN E. ROTHROCK , TIMOTHY L. RATLIFFTIMOTHY L. RATLIFF , and BRIDGET ZIMMERMANBRIDGET ZIMMERMAN View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)67152-2AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Although patients with interstitial cystitis frequently report symptom exacerbation due to stress, to our knowledge this association has not been empirically examined. We evaluated the effects of a laboratory mental stress challenge on symptoms of urgency and pain in patients with interstitial cystitis and healthy controls. Materials and Methods: A total of 14 females with interstitial cystitis and 14 age matched controls participated in a laboratory session, including a 60-minute baseline measurement, 25 minutes of mental stress tasks and 75 minutes of recovery. Acute symptoms of pain and urgency were assessed at voiding 15 minutes before the stressor, and 25, 70 and 100 minutes after stressor onset. Chronic symptoms were evaluated by questions from the Interstitial Cystitis Data Base survey. Results: Patients reported significantly greater pain and urgency than controls at all 4 voidings (p <0.005). Pain increased in patients from the prestressor point to 25 minutes after stressor onset (p <0.005), remained elevated at 70, and decreased between 70 and 100. At 100 minutes patient pain remained significantly elevated above baseline (p = 0.018). Patient urgency was significantly elevated over baseline by 70 minutes after stressor onset (p <0.001) and significantly decreased between 70 and 100 minutes (p <0.002). Controls had no symptom changes with stress. Conclusions: These findings indicate that an acute stressor evokes increased symptoms of pain and urgency in patients with interstitial cystitis but not in controls. Findings are consistent with sympathetic effects on inflammatory processes in interstitial cystitis. However, further evaluation of the mechanisms underlying stress related interstitial cystitis symptom exacerbation is needed to provide a more comprehensive understanding of these phenomena. References 1 : Diagnosis of interstitial cystitis. J Urol1990; 143: 278. Link, Google Scholar 2 : The natural history of interstitial cystitis: a survey of 374 patients. J Urol1993; 149: 465. Link, Google Scholar 3 : The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. 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Google Scholar From the Departments of Psychology, Urology, and Preventive Medicine and Biostatistics, University of Iowa, Iowa City, Iowa© 2000 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited BySutcliffe S, Jemielita T, Lai H, Andriole G, Bradley C, Clemens J, Gallop R, Hooton T, Kreder K, Krieger J, Kusek J, Labus J, Lucia M, Mackey S, Naliboff B, Robinson N, Rodriguez L, Stephens-Shields A, van Bokhoven A, Wolin K, Yan Y, Yang C, Landis J and Colditz G (2018) A Case-Crossover Study of Urological Chronic Pelvic Pain Syndrome Flare Triggers in the MAPP Research NetworkJournal of Urology, VOL. 199, NO. 5, (1245-1251), Online publication date: 1-May-2018.Seth A and Teichman J (2018) Differences in the Clinical Presentation of Interstitial Cystitis/Painful Bladder Syndrome in Patients With or Without Sexual Abuse HistoryJournal of Urology, VOL. 180, NO. 5, (2029-2033), Online publication date: 1-Nov-2008.LUTGENDORF S, LATINI J, ROTHROCK N, ZIMMERMAN M and KREDER K (2018) AUTONOMIC RESPONSE TO STRESS IN INTERSTITIAL CYSTITISJournal of Urology, VOL. 172, NO. 1, (227-231), Online publication date: 1-Jul-2004.Rothrock N, Lutgendorf S, Hoffman A and Kreder K (2018) Depressive Symptoms And Quality Of Life In Patients With Interstitial CystitisJournal of Urology, VOL. 167, NO. 4, (1763-1767), Online publication date: 1-Apr-2002.LUTGENDORF S, KREDER K, ROTHROCK N, HOFFMAN A, KIRSCHBAUM C, STERNBERG E, ZIMMERMAN M and RATLIFF T (2018) DIURNAL CORTISOL VARIATIONS AND SYMPTOMS IN PATIENTS WITH INTERSTITIAL CYSTITISJournal of Urology, VOL. 167, NO. 3, (1338-1343), Online publication date: 1-Mar-2002.WESTROPP J and BUFFINGTON C (2018) IN VIVO MODELS OF INTERSTITIAL CYSTITISJournal of Urology, VOL. 167, NO. 2 Part 1, (694-702), Online publication date: 1-Feb-2002. Volume 164Issue 4October 2000Page: 1265-1269 Advertisement Copyright & Permissions© 2000 by American Urological Association, Inc.Keywordspainbladderstress, psychologicalurination disorderscystitis, interstitialMetricsAuthor Information SUSAN K. LUTGENDORF More articles by this author KARL J. KREDER More articles by this author NAN E. ROTHROCK More articles by this author TIMOTHY L. RATLIFF More articles by this author BRIDGET ZIMMERMAN More articles by this author Expand All Advertisement PDF DownloadLoading ...
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