Potential anticancer agents. XXVI. Spin Labelled Nitrosoureas
1985; Wiley; Volume: 327; Issue: 4 Linguagem: Inglês
10.1002/prac.19853270418
ISSN0021-8383
AutoresI. BARACU, V. DOBRE, Ion Niculescu‐Duvaz,
Tópico(s)Lanthanide and Transition Metal Complexes
ResumoAbstract In order to obtain more information about the in vivo mechanism of action of nitrosoureas, the synthesis of spin labelled nitrosoureas derived from 1‐oxyl‐2.2.6.6‐tetramethyl‐4‐aminopiperidine was undertaken. The synthesis of four spin labelled ureas 4a–4d was reported as well as two spin labelled nitrosoureas:1‐methyl‐3‐(2′.2′.6′.6.′‐tetramethyl‐piperidin‐4′‐yl‐1′‐oxyl)‐1‐nitrosourea( 9a ) and 1‐(2′‐chloroethyl)‐3‐(2″,2″.6″.6″‐tetramethyl‐piperidin‐4″‐yl‐1″‐oxyl)‐nitrosourea (9b) . Their e.s.r. spectra were recorded. None of these compounds proved to be active against L1210.
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