A homogeneous population of lymphokine-activated killer (LAK) cells is incapable of killing virus-, bacteria-, or parasite-infected macrophages
1990; Elsevier BV; Volume: 125; Issue: 1 Linguagem: Inglês
10.1016/0008-8749(90)90080-b
ISSN1090-2163
AutoresArturo Zychlinsky, Michele Karim, Ruta Nonacs, John D. Young,
Tópico(s)Toxoplasma gondii Research Studies
ResumoPrevious reports have suggested a role for natural killer (NK) cells in directly lysing host cells infected with bacteria and other intracellular microorganisms. Here, we determined the inability of a highly homogeneous population of lymphokine activated killer (LAK) cells to kill macrophages infected with the following intracellular parasites: Mycobacterium avium, Listeria monocytogenes, Legionella pneumophila, Toxoplasma gondii, and Trypanosoma cruzi. In parallel cytotoxicity assays, LAK cells lysed the tumor targets YAC-1 and P815 effectively. Furthermore, we were able to demonstrate that influenza-specific cytotoxic T lymphocytes (CTL), but not LAK cells, were efficient killers of influenza virus-infected macrophages.
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