Toxic effects of 1-decyl-3-methylimidazolium bromide ionic liquid on the antioxidant enzyme system and DNA in zebrafish (Danio rerio) livers
2013; Elsevier BV; Volume: 91; Issue: 8 Linguagem: Inglês
10.1016/j.chemosphere.2013.01.013
ISSN1879-1298
AutoresMiao Dong, Lusheng Zhu, Shaoyuan Zhu, Jinhua Wang, Jun Wang, Hui Xie, Zhongkun Du,
Tópico(s)Ionic liquids properties and applications
ResumoIonic liquids were recently found to be toxic to aquatic organisms. Therefore, the present study investigated the effects of 1-decyl-3-methylimidazolium bromide ([C10mim]Br) on oxidative stress and DNA damage in zebrafish. Male and female zebrafish were separated and exposed to five concentrations of [C10mim]Br (0, 5, 10, 20, and 40 mg L−1) and were sampled on days 7, 14, 21 and 28. Compared to control groups, the activities of antioxidant enzymes were significantly decreased at most exposure intervals. This decreased activity resulted in the production of excess reactive oxygen species (ROS) and increased malondialdehyde (MDA) content in zebrafish liver. Additionally, it was noteworthy that a clear dose-response was found for DNA damage. As for sex differences, significant differences in catalase (CAT) and ROS were found on the 7th day. In conclusion, the exposure of [C10mim]Br caused DNA damage, leading to antioxidant responses in zebrafish livers.
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