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Radiation-related Leukemia in Hiroshima and Nagasaki 1946-1964

1967; American College of Physicians; Volume: 66; Issue: 3 Linguagem: Inglês

10.7326/0003-4819-66-3-522

1539-3704

O. Joseph Bizzozero,

DNA Repair Mechanisms

Article1 March 1967Radiation-related Leukemia in Hiroshima and Nagasaki 1946-1964II. Observations on Type-specific Leukemia, Survivorship, and Clinical BehaviorO. JOSEPH BIZZOZERO JR., M.D., KENNETH G. JOHNSON, M.D., ANTONIO CIOCCO, SC.D., SHO KAWASAKI, M.D., SHIGEKI TOYODA, M.D.O. JOSEPH BIZZOZERO JR., M.D., KENNETH G. JOHNSON, M.D., ANTONIO CIOCCO, SC.D., SHO KAWASAKI, M.D., SHIGEKI TOYODA, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-3-522 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecently, we reported on the experience of the Atomic Bomb Casualty Commission (ABCC) in the detection of leukemia in the populations of Hiroshima and Nagasaki, Japan, for the period 1946 to 1964 (1). The years 1946 to 1954 exhibited extremely high incidence rates for leukemia in those persons exposed 0 to 1,500 m from the atomic bombs' hypocenters. This period reflected maximal radiation effect. In addition, attention was invited both to the induction of chronic leukemia at a remarkably high rate in persons who were less than 30 years of age at the time of the bombings (ATB) and to...References1. BIZZOZEROJOHNSONCIOCCO OJKGA in collaboration with HOSHINO, T., ITOGA, T., TOYODA, S., KAWASAKI, S.: Radiation related leukemia in Hiroshima and Nagasaki 1946-64. I. Distribution, incidence, and appearance times. New Eng. J. Med. 274: 1095, 1966. CrossrefMedlineGoogle Scholar2. FINCHHRUBECNEFZGERHOSHINOITOGA SCZMTT: Detection of leukemia and related disorders, Hiroshima and Nagasaki. Atomic Bomb Casualty Commission Technical Report, 05-65, pp. 1-22. Google Scholar3. ISHIDABEEBE MGW: Research plan for joint JNIH-ABCC study of life span of A-bomb survivors. Atomic Bomb Casualty Commission Technical Report, 04-59, pp. 1-89. Google Scholar4. MACMAHONCLARK BD: Incidence of the common forms of human leukemia. Blood 11: 871, 1956. 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BUCKTONJACOBSCOURT-BROWNDOLL KEPAWMR: A study of the chromosome damage persisting after x-ray therapy for ankylosing spondylitis. Lancet 2: 676, 1962. CrossrefMedlineGoogle Scholar17. BENDERGOOCH MAPC: Persistent chromosome aberrations in irradiated human subjects. II. Three and one-half year investigation. Radiat. Res. 18: 389, 1963. CrossrefMedlineGoogle Scholar18. BLOOMNERIISHIKAMADAISEKIKEEHN ADSNTRJ: Cytogenetic investigations of survivors of the atomic bombings of Hiroshima and Nagasaki. Lancet 2: 672, 1966. CrossrefMedlineGoogle Scholar19. NOWELLHUNGERFORDCOLE PCDALJ: Chromosome changes following irradiation in mammals. Ann. N. Y. Acad. Sci. 114: 252, 1964. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: O. JOSEPH BIZZOZEROJR., M.D.; KENNETH G. JOHNSON, M.D.; ANTONIO CIOCCO, SC.D.; SHO KAWASAKI, M.D.; SHIGEKI TOYODA, M.D.Affiliations: Hiroshima and Nagasaki,From the Atomic Bomb Casualty Commission, Hiroshima and Nagasaki, Japan, a cooperative research agency of the U. S. National Academy of Sciences-National Research Council and the Japanese National Institute of Health of the Ministry of Health and Welfare.This study was supported by the U. S. Atomic Energy Commission, Oak Ridge, Tenn., the Japanese National Institute of Health, and the U. S. Public Health Service, Washington, D. C.Dr. Kawasaki is a James Hudson Brown Research Fellow, Yale University, New Haven, Conn.Requests for reprints should be addressed to Editorial Office, Atomic Bomb Casualty Commission, Hijiyama Park, Hiroshima,Japan. 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