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Rat Small Intestine Muscle Relaxation Alkaloids from Orixa japonica Leaves.

2001; Pharmaceutical Society of Japan; Volume: 24; Issue: 1 Linguagem: Inglês

10.1248/bpb.24.100

1347-5215

Shinji Funayama, Rioko TANAKA, Yasuhiro KUMEKAWA, Toshiro Noshita, Tetsuya Mori, Tadashi Kashiwagura, Kiyoshi Murata,

Pharmacological Effects of Natural Compounds

Two quinoline alkaloids, japonine (1) and eduline (2) were isolated from the methanol extract of the leaves of Orixa japonica as relaxants against rat small intestine muscle. The activity of these alkaloids was comparable to that of the typical muscle relaxant papaverine (4). This is also the first report of the isolation of eduline (2) from O. japonica.