GSTP1 mRNA expression in human circulating blood leukocytes is associated with GSTP1 genetic polymorphism
2011; Elsevier BV; Volume: 44; Issue: 13 Linguagem: Inglês
10.1016/j.clinbiochem.2011.05.024
ISSN1873-2933
AutoresEdyta Reszka, Zbigniew Jabłonowski, Edyta Wieczorek, Jolanta Gromadzińska, Marek Sosnowski, Wojciech Wąsowicz,
Tópico(s)Pharmacogenetics and Drug Metabolism
ResumoWe explored association between GSTP1 Ile105Val (rs1695) polymorphism and GSTP1 mRNA expression in circulating blood leukocytes. GSTP1 transcripts level and polymorphism were determined by Real-Time PCR in 51 bladder cancer and 90 healthy men. Individuals with at least one GSTP1 Val105 variant allele possessed higher GSTP1 mRNA level in blood leukocytes compared to GSTP1 Ile105Ile carriers. GSTP1 Ile105Val gene polymorphism influences its expression in blood, regardless of cancer disease.
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