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Brain perfusion SPET and proton magnetic resonance spectroscopy in the evaluation of two systemic lupus erythematosus patients with mild neuropsychiatric manifestations

1997; Lippincott Williams & Wilkins; Volume: 18; Issue: 3 Linguagem: Inglês

10.1097/00006231-199703000-00012

1473-5628

Paolo Colamussi, Francesco Trotta, R. Ricci, Corrado Cittanti, Marcello Govoni, Giovanna Barbarella, Melchiore Giganti, Gianluigi Bajocchi, Licia Uccelli, C. Trevisan, A Piffanelli,

Photoacoustic and Ultrasonic Imaging

The diagnosis of central nervous system (CNS) involvement appears to be a major problem in systemic lupus erythematosus (SLE), especially when the clinical signs are non-specific or neuroimaging is unremarkable. Two SLE patients with mild neuropsychiatric manifestations were studied with magnetic resonance imaging (MRI), single photon emission tomography (SPET) and localized proton magnetic resonance spectroscopy (H-1 MRS). MRI was normal in both patients. SPET revealed areas of hypoperfusion in both patients. H-1 MRS demonstrated metabolic abnormalities in the regions corresponding to the hypoperfused areas. A correlation between H-1 MRS and SPET was noted: patients with mild neuropsychiatric SLE may have disturbances evident on SPET and H-1 MRS in the presence of normal anatomy on MRI, suggesting that CNS involvement in SLE has very strong physiological and neurometabolic components in individual patients.