A Novel Anti-HBeAg Homolignan, Taiwanschirin D from Kadsura matsudai.
2000; Pharmaceutical Society of Japan; Volume: 48; Issue: 12 Linguagem: Inglês
10.1248/cpb.48.1992
ISSN1347-5223
AutoresShyh‐Yuan Li, Ming‐Der Wu, Chi‐We Wang, Yao‐Haur Kuo, Ray‐Ling Huang, Kuo‐Hsiung Lee,
Tópico(s)Bioactive natural compounds
ResumoA novel C19 homolignan, taiwanschirin D (1), possessing a 3, 4-{1-[(Z)-2-methoxy-2-oxoethylidene]}pentano (2, 3-dihydrobenzo[b]furan)-3(2-oxoacetate) skeleton, was isolated from the stem of Kadsura matsudai HAYATA. Its structure was determined from physical and spectral data including 2D NMR spectra. The Anti-HBeAg test revealed that taiwanschirin D (1) had moderate activity at a concentration of 94.3μM (50μg/ml).
Referência(s)