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Immunoglobulin allotypic markers in Kawasaki disease

1993; Elsevier BV; Volume: 122; Issue: 1 Linguagem: Inglês

10.1016/s0022-3476(05)83493-6

1097-6833

Stanford T. Shulman, Marian E. Melish, Osmu Inoue, Hirohisa Kato, S Tomita,

Coronary Artery Anomalies

We investigated the possible relationship of the distribution of immunoglobulin allotypic markers for susceptibility to Kawasaki disease in Japanese, Japanese-American, and white American populations. The kappa-chain allotype Km1 was present in 25.6% of sera from white patients with Kawasaki disease and in 14.4% of control sera (p < 0.01), and the combination of Km1 with Gm heterozygosity was present in 17.9% of white patients with Kawasaki disease and in 6.4% of control sera (p < 0.0001). In all populations studied, differences were observed between the patients with Kawasaki disease and the race-matched control subjects. The findings support the hypothesis that one or more unknown infectious agents may trigger genetically influenced immune responses that result in clinically recognizable Kawasaki disease.