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hChAT: A Tool for the Chemoenzymatic Generation of Potential Acetyl/Butyrylcholinesterase Inhibitors

2009; Wiley; Volume: 10; Issue: 13 Linguagem: Inglês

10.1002/cbic.200900309

1439-7633

Keith Green, Micha Fridman, Sylvie Garneau‐Tsodikova,

Computational Drug Discovery Methods

ChemBioChemVolume 10, Issue 13 p. 2191-2194 Communication hChAT: A Tool for the Chemoenzymatic Generation of Potential Acetyl/Butyrylcholinesterase Inhibitors Keith D. Green Dr., Keith D. Green Dr. Department of Medicinal Chemistry in The College of Pharmacy and The Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI, 48109 (USA), Fax: (+1) 734-615-5521Search for more papers by this authorMicha Fridman Dr., Micha Fridman Dr. School of Chemistry, Tel Aviv University, Tel Aviv 66978 (Israel)Search for more papers by this authorSylvie Garneau-Tsodikova Dr., Sylvie Garneau-Tsodikova Dr. [email protected] Department of Medicinal Chemistry in The College of Pharmacy and The Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI, 48109 (USA), Fax: (+1) 734-615-5521Search for more papers by this author Keith D. Green Dr., Keith D. Green Dr. Department of Medicinal Chemistry in The College of Pharmacy and The Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI, 48109 (USA), Fax: (+1) 734-615-5521Search for more papers by this authorMicha Fridman Dr., Micha Fridman Dr. School of Chemistry, Tel Aviv University, Tel Aviv 66978 (Israel)Search for more papers by this authorSylvie Garneau-Tsodikova Dr., Sylvie Garneau-Tsodikova Dr. [email protected] Department of Medicinal Chemistry in The College of Pharmacy and The Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI, 48109 (USA), Fax: (+1) 734-615-5521Search for more papers by this author First published: 27 August 2009 https://doi.org/10.1002/cbic.200900309Citations: 17Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract Let′s ChAT about AD: We have successfully developed a chemoenzymatic methodology that utilizes the human choline acetyltransferase (hChAT) for the production of potential acetyl/buturylcholinesterase inhibitors to target Alzheimer's disease (AD). We have kinetically characterized and demonstrated the promisucity of this enzyme for choline analogue substrates and coenzyme A cosubstrates. Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description cbic_200900309_sm_miscellaneous_information.pdf382.1 KB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. 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