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Detection of circulating antigen in bancroftian filariasis by sandwich ELISA using filarial serum IgG

1984; Cambridge University Press; Volume: 58; Issue: 3 Linguagem: Inglês

10.1017/s0022149x00027103

1475-2697

M. V. R. Reddy, Ashok Malhotra, B. C. Harinath,

Insects and Parasite Interactions

ABSTRACT The utility of the IgG fraction of human filarial serum immunoglobulin in detecting circulating antigen by sandwich enzyme linked immunosorbent assay (ELISA) was studied. 27 of 33 sera from persons with microfilaracmia, 19 of 30 sera from clinical cases of filariasis, 4 of 30 sera from normal persons from a region endemic for filariasis showed the presence of circulating filarial antigen. All the 20 normal sera from the area where filariasis was not endemic gave negative reaction for filarial antigen. Those sera from persons with microfilaracmia that showed the presence of circulating antigen also showed an apparent positive correlation between the microfilarial density and the antigen titre.