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Perfil epidemiológico da espondiloartrite de início juvenil comparada com a espondiloartrite de início na vida adulta em uma grande coorte brasileira

2014; Elsevier BV; Volume: 54; Issue: 6 Linguagem: Inglês

10.1016/j.rbr.2014.06.005

1809-4570

Ângela Luzia Branco Pinto Duarte, Cláudia Diniz Lopes Marques, Adriana Bruscato Bortoluzzo, Célio Roberto Gonçalves, José Antonio Braga da Silva, Antônio Carlos Ximenes, Manoel Barros Bértolo, Sandra Lúcia Euzébio Ribeiro, Mauro Waldemar Keiserman, Thelma Larocca Skare, Sueli Carneiro, Rita Menin, Valderílio Feijó Azevedo, Walber Pinto Vieira, Elisa N. Albuquerque, Washington A. Bianchi, Rubens Bonfiglioli, Cristiano Campanholo, Hellen M.S. Carvalho, Izaías Pereira da Costa, Charles Lubianca Kohem, Nocy Leite, Sonia A.L. Lima, Eduardo S. Meirelles, Ivânio Alves Pereira, Marcelo M. Pinheiro, Elizandra Polito, Gustavo Gomes Resende, Francisco Airton Castro Rocha, Mittermayer Barreto Santiago, Maria de Fátima L.C. Sauma, Valéria Valim, Percival D. Sampaio‐Barros,

Autoimmune and Inflammatory Disorders Research

To analyze the clinical and epidemiologic characteristics of juvenile-onset spondyloarthritis (SpA) (< 16 years) and compare them with a group of adult-onset (≥ 16 years) SpA patients.Prospective, observational and multicentric cohort with 1,424 patients with the diagnosis of SpA according to the European Spondyloarthropathy Study Group (ESSG) submitted to a common protocol of investigation and recruited in 29 reference centers participants of the Brazilian Registry of Spondyloarthritis (RBE - Registro Brasileiro de Espondiloartrites). Patients were divided in two groups: age at onset<16 years (JOSpA group) and age at onset ≥ 16 years (AOSpA group).Among the 1,424 patients, 235 presented disease onset before 16 years (16.5%). The clinical and epidemiologic variables associated with JOSpA were male gender (p<0.001), lower limb arthritis (p=0.001), enthesitis (p=0.008), anterior uveitis (p=0.041) and positive HLA-B27 (p=0.017), associated with lower scores of disease activity (Bath Ankylosing Spondylitis Disease Activity Index - BASDAI; p=0.007) and functionality (Bath Ankylosing Spondylitis Functional Index - BASFI; p=0.036). Cutaneous psoriasis (p<0.001), inflammatory bowel disease (p=0.023), dactylitis (p=0.024) and nail involvement (p=0.004) were more frequent in patients with adult-onset SpA.Patients with JOSpA in this large Brazilian cohort were characterized predominantly by male gender, peripheral involvement (arthritis and enthesitis), positive HLA-B27 and lower disease scores.