Application of Electrochemical Detection for the Quantitation of 1, 4-Dihydroxy-5, 8-Bis-[2-(2-Hydroxyethyl) Aminoethylamino]-9,10-Anthracenedione Following Liquid Chromatography
1983; Taylor & Francis; Volume: 16; Issue: 16 Linguagem: Inglês
10.1080/00032718308065248
ISSN1532-236X
AutoresSteven T. Houpt, Richard P. Baldwin,
Tópico(s)Molecular Sensors and Ion Detection
ResumoAbstract Electrochemical monitoring of 1, 4-dihydroxy-5, 8-bis-[2-(2-hydroxyethy1) aminoethy amino]-9, 10-anthracenedione was employed for the quantitation of this cancer chemotherapy drug following high performance liquid chromatography. Detection was performed by oxidation of the compound at a glassy carbon electrode at +0.80 V vs. SCE. A rapid and convenient sample treatment procedure was developed which is suitable for determination involving physiological samples. A detection limit of 2 ng injected was obtained for urine samples. Key Words: 1, 4-dihydroxy-58-bis[2-(2- hydroxyethy1) aminoethylamino]-910-anthracenedioneliquid chromatography with electrochemical detection
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