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Different temporal effects of serotonergic antagonists on passive avoidance retention

1987; Elsevier BV; Volume: 28; Issue: 3 Linguagem: Inglês

10.1016/0091-3057(87)90452-7

1873-5177

Harvey J. Altman, Howard J. Normile,

Nicotinic Acetylcholine Receptors Study

The experiments examined the effects of acute administration of three different serotonergic receptor antagonists (ketanserin, pirenperone and mianserin) on one-trial passive avoidance retention in mice. Administration of each antagonist 30 min before training produced a dose-dependent impairment in retention. In contrast, administration of each of the antagonists immediately after training produced a dose-dependent improvement in retention. The time-dependent effects of pre- and post-train antagonist administration were assessed using pirenperone. In both cases, the effects on test performance were determined to be time-dependent. The results provide additional evidence suggestive of a differential role of the serotonergic nervous system in the processes underlying learning and memory.