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Isolation and characterization of fatty acid-binding protein from rat brain

1985; Elsevier BV; Volume: 236; Issue: 2 Linguagem: Inglês

10.1016/0003-9861(85)90671-x

1096-0384

Masanori Senjo, Teruo Ishibashi, Yoh Imai, Kuni Takahashi, Teruo Ono,

Immune Response and Inflammation

A fatty acid-binding protein has been identified and isolated from the cytosol fraction of rat brain. The fatty acid-binding protein was purified to homogeneity by gel filtration and preparative isoelectric focusing. The binding protein was different from Z protein from rat liver in its isoelectric point and immunological reactivity, in spite of its similar molecular weight of 12,000. Rabbit antibodies against rat liver Z protein were used to demonstrate that the fatty acid-binding proteins from rat liver and brain are immunologically unrelated, and that no Z protein is present in rat brain Cytosol.