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Revisão Acesso aberto Produção Nacional
BIBTEX RIS

Thyroid spindle epithelial tumor with thymus-like differentiation (SETTLE): case report and review

2010; Editora da Universidade de São Paulo; Volume: 54; Issue: 7 Linguagem: Inglês

10.1590/s0004-27302010000700011

ISSN

1677-9487

Autores

Luiz Antonio Magnata da Fonte Filho, Maria Alice Neves Bordallo, Cencita H. C. N. Pessoa, Rossana Corbo, Daniel Bulzico, Fernando Luiz Dias, A. Machado, Andréia B. Soares, Sima Ferman,

Tópico(s)

Pituitary Gland Disorders and Treatments

Resumo

Spindle epithelial tumor with thymus-like element (SETTLE) is a rare malignant neoplasm of the thyroid, occurring predominantly in children, adolescents, and young adults. SETTLE usually presents itself as a thyroid mass, without metastases at diagnosis. It is believed to derive from branchial pouch or thymic remnant tissue showing primitive thymic differentiation. This article reports the clinical, cytological, histological and immunohistochemical features of a SETTLE in a 3-year-old girl. Microscopic exam revealed a nodular, highly cellular neoplasm displayed in the classic biphasic pattern, with mixture of prominent spindle cell component and a minor glandular component lined by mucinous or respiratory-type epithelium. The immunohistochemical study showed strong and diffuse positivity for pan-CK, vimentin and smooth muscle actin. The present case is the first SETTLE case reported in Brazil. To date, the patient described remains without evidence of recurrence or metastasis 5 years after surgery.

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