Labeled bile acids VI: [22,23,24-13C3]-methyl 3α,7α-diacetoxy 5β-cholan-24-oate, [22,23,24-13c3]-methyl 3β-acetoxychol-5-en-24-oate, and [16,17,22,23-3h4]-methyl 3β-acetoxychol-5-en-24-oate (1)

Artigo Revisado por pares

Labeled bile acids VI: [22,23,24-13C3]-methyl 3α,7α-diacetoxy 5β-cholan-24-oate, [22,23,24-13c3]-methyl 3β-acetoxychol-5-en-24-oate, and [16,17,22,23-3h4]-methyl 3β-acetoxychol-5-en-24-oate (1)

1986; Wiley; Volume: 23; Issue: 9 Linguagem: Inglês

10.1002/jlcr.2580230907

ISSN

1099-1344

Autores

Chee Kong Lai, Chang Yon Byon, Warren G. Anderson, Marcel Gut,

Tópico(s)

Molecular Sensors and Ion Detection

Resumo

Abstract A general short procedure for the introduction of 13 C to the side chain of bile acids is described. Suitable ( Z )‐pregn‐17(20)‐enes are key intermediates, while the isotope is introduced by an ene reaction with [1,2,3‐ 13 C 3 ]‐methyl propiolate. For the labeling with tritium, the unlabeled product of the ene synthesis, a Δ 5,16,22 ‐triene was saturated selectively at 16,17 and 22,23 with tritium gas.

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Labeled bile acids VI: [22,23,24-13C3]-methyl 3α,7α-diacetoxy 5β-cholan-24-oate, [22,23,24-13c3]-methyl 3β-acetoxychol-5-en-24-oate, and [16,17,22,23-3h4]-methyl 3β-acetoxychol-5-en-24-oate (1)