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HyperCKemia as the Only Sign of McArdle's Disease in a Child

2000; SAGE Publishing; Volume: 15; Issue: 2 Linguagem: Inglês

10.1177/088307380001500216

1708-8283

Claudio Bruno, Enrico Bertini, Filippo M. Santorelli, Salvatore DiMauro,

Neurological and metabolic disorders

An asymptomatic 13-year-old boy, who never complained of exercise intolerance or myalgia, was found to have markedly elevated serum creatine kinase (CK) levels during a routine check-up. General physical and neurologic examinations were normal. Surprisingly, histochemical and biochemical analysis of muscle showed myophosphorylase deficiency and genetic analysis showed that the patient was homozygous for the most common mutation encountered in McArdle's disease (R49X). This case illustrates the fuzzy correlation between molecular defect and clinical phenotype in patients with McArdle's disease, and suggests that a thorough study of the muscle biopsy is important in patients with idiopathic hyperCKemia for correct diagnosis and careful follow-up. ( J Child Neurol 2000;15:137-138).