Produção Nacional
Revisado por pares
Infection and disease in human schistosomiasis mansoni are under distinct major gene control
1999; Elsevier BV; Volume: 1; Issue: 7 Linguagem: Inglês
10.1016/s1286-4579(99)80096-3
ISSN1769-714X
AutoresAlain Dessein, Sandrine Marquet, Sandrine Henri, Nasr Eldin M.A El Wali, Dominique Hillaire, Virmondes Rodrigues, Áluízio Prata, Mohamed S. Ali, Bouchra Gharib, Max de Reggi, Mubarak Magzoub, Osman K Saeed, Ahmed A. Abdelhameed, Laurent Abel,
Tópico(s)Research on Leishmaniasis Studies
ResumoSubclinical morbidity due to schistosomiasis was evaluated in 565 patients, and the enhanced liver fibrosis (ELF) test was assessed for the first time as a potential screening tool for disease.The prevalence and intensity of infection were determined by Kato–Katz thick smear stool examination at baseline and 2 years after curative treatment. The degree of hepatic fibrosis was assessed by ultrasound. Non-invasive serum biomarkers of hepatic fibrosis were also evaluated.The baseline human prevalence and infection intensity were found to be moderately high at 34% and 123 eggs per gram, respectively. However, hepatic parenchymal fibrosis occurred in 50% of subjects, with grade II fibrosis in 19% and grade III in 6%. The ELF score and higher serum levels of tissue inhibitor of metalloproteinase 1 (TIMP-1) and hyaluronic acid (HA) correlated with the grade of liver fibrosis.The findings of this study demonstrated that praziquantel treatment had a short-term impact on both the prevalence and intensity of infection, but less of an impact on established morbidity. Higher TIMP-1 and HA serum levels, and an ELF cut-off score of 8 were found to be correlated with the grade of liver fibrosis; these values may, therefore, assist physicians in identifying individuals at greater risk of disease.
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