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Hepatotoxicity in Rat Following Administration of Valproic Acid: Effect of L‐Carnitine Supplementation

1987; Wiley; Volume: 28; Issue: 4 Linguagem: Inglês

10.1111/j.1528-1157.1987.tb03660.x

1528-1167

Tateo Sugimoto, Atsushi Araki, Naoki Nishida, Yoshimi Sakane, Man Woo, Taishi Takeuchi, Yohnosuke Kobayashi,

Metabolism and Genetic Disorders

Summary: The effect of prolonged administration (7 days) of valproate (VPA, 500 mg/kg/day), or VPA (500 mglkglday) with L‐carnitine (200 mg/kg/day) on blood carnitine levels and the appearance of liver mitochondria were assessed in the rat. VPA‐treated rats showed hypo‐ carnitinemia and enlarged mitochondria when compared with saline‐injected control rats. In rats treated with bothVPA and L‐carnitine, serum and liver carnitine levels were increased by the L‐carnitine supplement and the liver mitochondria were not enlarged. L‐Carnitine supplement in VPA‐medicated patients seems to prevent hepatotoxicity, especially mitochondrial dysfunction.