Increased Vitamin A and E Levels in Adult Cystic Fibrosis Patients after Lung Transplantation
2005; Wolters Kluwer; Volume: 79; Issue: 5 Linguagem: Inglês
10.1097/01.tp.0000151660.69796.10
ISSN1534-6080
AutoresAnne L. Stephenson, Michelle Brotherwood, Ronalee Robert, Peter Durie, Zul Verjee, Cecilia Chaparro, Mary Corey, Elizabeth Tullis,
Tópico(s)Pharmacological Effects and Toxicity Studies
ResumoMost patients with cystic fibrosis (CF) and pancreatic insufficiency require supplementation with fat-soluble vitamins to maintain normal serum levels. Even with supplementation, toxicity is rare. We evaluated serum vitamin A and E levels in 23 adult patients with CF who underwent double lung transplantation. Twenty-one of the subjects were pancreatic insufficient. Fifteen subjects had serum vitamin levels before and after transplant. The median time posttransplantation for these subjects was 9 months. Mean serum vitamin A and E levels were significantly higher posttransplantation (P<0.0001, P<0.001, respectively). Eight subjects who only had posttransplant vitamin levels also had abnormally high vitamin A levels. Although the etiology of this novel finding is unclear, possibilities include altered absorption, drug interactions, impaired retinol metabolism, or increased hepatic synthesis of retinol binding protein.
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