An approach to the synthesis of peptide–PNA–peptide conjugates via native ligation
2002; Elsevier BV; Volume: 43; Issue: 45 Linguagem: Inglês
10.1016/s0040-4039(02)01856-7
ISSN1873-3581
AutoresMartijn C. de Koning, Dmitri V. Filippov, Nico J. Meeuwenoord, Mark Overhand, Gijs A. van der Marel, Jacques H. van Boom,
Tópico(s)DNA and Nucleic Acid Chemistry
ResumoA convenient solid-phase synthesis of a PNA sequence containing an N-terminal thiaproline and a C-terminal thioester is described. The usefulness of this bifunctional PNA molecule is illustrated by the construction, based on native ligation, of a peptide–PNA–peptide adduct.
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