Determination of psilocin and psilocybin using flow injection analysis with acidic potassium permanganate and tris(2,2′-bipyridyl)ruthenium(II) chemiluminescence detection respectively
2005; Elsevier BV; Volume: 67; Issue: 2 Linguagem: Inglês
10.1016/j.talanta.2004.11.038
ISSN1873-3573
AutoresNicole Anastos, Neil W. Barnett, Simon W. Lewis, Nicholas Gathergood, Peter J. Scammells, Dorothy A. Sims,
Tópico(s)Neurotransmitter Receptor Influence on Behavior
ResumoA simple, rapid and sensitive method for the determination of psilocin and psilocybin is described. This is the first report on the determination of psilocin and psilocybin using flow injection analysis with acidic potassium permanganate and tris(2,2'-bipyridyl)ruthenium(II) chemiluminescence. The limits of detection (signal-to-noise ratio=3) are 9x10(-10)M and 3x10(-10)M for psilocin and psilocybin, respectively. A concise synthetic route for psilocin in three steps from readily available starting materials is also described. The structures were elucidated on the basis of spectroscopic data.
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