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Activities of enzymes that hydrolyze adenine nucleotides in platelets from patients with rheumatoid arthritis

2010; Elsevier BV; Volume: 43; Issue: 13-14 Linguagem: Inglês

10.1016/j.clinbiochem.2010.06.011

1873-2933

Lara Vargas Becker, Cíntia Saydelles da Rosa, Viviane do Carmo Gonçalves Souza, Margarete Dulce Bagatini, Émerson André Casali, Cláudio A.M. Leal, João Carlos N. da Silva, Maria Beatriz Moretto, Francielle de Vargas Pinheiro, Vera Maria Morsch, Maria Rosa Chitolina Schetinger, Daniela Bitencourt Rosa Leal,

Autoimmune and Inflammatory Disorders Research

To investigate whether there are changes in the activity of the enzymes NTPDase, 5'-nucleotidase, E-NPP and ADA in platelets from patients with rheumatoid arthritis (RA).Thirty-five RA patients diagnosed with RA through American College of Rheumatology criteria, as well as 35 healthy patients were selected. NTPDase, 5'-nucleotidase, E-NPP and ADA activities were verified in platelets isolated from these patients.The results demonstrate that an increase in NTPDase (approximately 100%), 5'-nucleotidase (170%), E-NPP (approximately 100%) and ADA (approximately 45%) activities occurred in RA patients when compared to the control group.Ours results suggest an increase in the NTPDase, 5'-nucleotidase and E-NPP activities, which could be related to a compensatory organic response to excessive platelet aggregation which occurs during the inflammation. The increased ADA activity found in this work could lead to a decrease in the adenosine concentration in the circulation, which could explain the accelerated atherosclerosis found in patients with RA.