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SENSITIVITY OF HUMAN COMPLEMENT FACTOR H RELATED PROTEIN (BTA STAT) TEST AND VOIDED URINE CYTOLOGY IN THE DIAGNOSIS OF BLADDER CANCER

2000; Lippincott Williams & Wilkins; Volume: 163; Issue: 6 Linguagem: Inglês

10.1016/s0022-5347(05)67521-0

1527-3792

Mika Raitanen, Timo Marttila, Eero Kaasinen, Erkki Rintala, Risto Aine, Teuvo L.J. Tammela, Teuvo L.J. Tammela,

Immunotherapy and Immune Responses

No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Jun 2000SENSITIVITY OF HUMAN COMPLEMENT FACTOR H RELATED PROTEIN (BTA STAT) TEST AND VOIDED URINE CYTOLOGY IN THE DIAGNOSIS OF BLADDER CANCER MIKA-P. RAITANEN, TIMO MARTTILA, EERO KAASINEN, ERKKI RINTALA, RISTO AINE, TEUVO L.J. TAMMELA, TEUVO L.J. TAMMELA, and the FINNBLADDER GROUP MIKA-P. RAITANENMIKA-P. RAITANEN More articles by this author , TIMO MARTTILATIMO MARTTILA More articles by this author , EERO KAASINENEERO KAASINEN More articles by this author , ERKKI RINTALAERKKI RINTALA More articles by this author , RISTO AINERISTO AINE More articles by this author , TEUVO L.J. TAMMELATEUVO L.J. TAMMELA More articles by this author , TEUVO L.J. TAMMELATEUVO L.J. TAMMELA More articles by this author , and the FINNBLADDER GROUP More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)67521-0AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We compared the sensitivity of the BTA stat † Bion Diagnostic Sciences, Redmond, Washington. test, a rapid, noninvasive, qualitative urine test that detects bladder tumor associated antigen (human complement factor H related protein) in urine, to that of voided urine cytology in patients with primary bladder cancer. We also assessed the effect of tumor size, number, histological grade and stage on test sensitivity. Materials and Methods: We evaluated 151 patients with newly diagnosed bladder cancer in a prospective multicenter study. A voided urine sample obtained before transurethral bladder tumor resection was divided for culture, cytology and BTA stat testing. Results: Overall sensitivity of the BTA stat test and urine cytology for detecting primary bladder cancer was 81.5% and 30.3%, respectively (p <0.0001). The sensitivity of each test increased as tumor size, number, histological grade and stage increased. Conclusions: Sensitivity of the BTA stat test was superior to that of voided urine cytology in all tumor categories. This noninvasive, easy to perform, point of care test may have the potential to replace cytology for diagnosing bladder cancer. References 1 : Current status of urinary cytology in the evaluation of bladder neoplasms. Hum Pathol1990; 21: 886. Google Scholar 2 : Accuracy of cytological diagnosis of cancer of the urinary tract. Acta Cytol1964; 8: 186. Google Scholar 3 : Improved detection of recurrent bladder cancer using the Bard BTA stat Test. Urology1997; 50: 349. Google Scholar 4 : Complement factor H-related proteins are expressed in bladder cancer. Proceedings of the annual meeting of American Association for Cancer Research, San Diego, California1997; 38: 29. abstract 189. Google Scholar 5 : Human bladder tumor antigen is a member of the RCA (regulators of complement activation) gene family. J Urol1997; 157: 28. abstract 110. Google Scholar 6 : Complement factor H or a related protein is a marker for transitional cell cancer of the bladder. Clin Cancer Res1998; 4: 2511. Google Scholar 7 : BTA stat and BTA TRAK: a comparative evaluation of urine testing for the diagnosis of transitional cell carcinoma of the bladder. Eur Urol1999; 35: 89. Google Scholar 8 : Specificity of human complement factor H-related protein test (BARD BTA stat Test). Scand J Urol Nephrol1999; 33: 234. Google Scholar 9 : Comparison of the BTA stat Test with voided urine cytology and bladder wash cytology in the diagnosis and monitoring of bladder cancer. Eur Urol1999; 35: 52. 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Google Scholar From the Division of Urology and Department of Pathology, Tampere University Hospital, Tampere, Department of Surgery, Seinäjoki Hospital, Hyvinkää Hospital and Department of Urology, Helsinki University Hospital, Helsinki, Finland© 2000 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byBOMAN H, HEDELIN H, JACOBSSON S and HOLMÄNG S (2018) Newly Diagnosed Bladder Cancer: The Relationship of Initial Symptoms, Degree of Microhematuria and Tumor Marker StatusJournal of Urology, VOL. 168, NO. 5, (1955-1959), Online publication date: 1-Nov-2002.BOMAN H, HEDELIN H and HOLMäNG S (2018) FOUR BLADDER TUMOR MARKERS HAVE A DISAPPOINTINGLY LOW SENSITIVITY FOR SMALL SIZE AND LOW GRADE RECURRENCEJournal of Urology, VOL. 167, NO. 1, (80-83), Online publication date: 1-Jan-2002.RAITANEN M, MARTTILA T, NURMI M, ALA-OPAS M, NIEMINEN P, AINE R and TAMMELA T (2018) HUMAN COMPLEMENT FACTOR H RELATED PROTEIN TEST FOR MONITORING BLADDER CANCERJournal of Urology, VOL. 165, NO. 2, (374-377), Online publication date: 1-Feb-2001.GIANNOPOULOS A, MANOUSAKAS T, GOUNARI A, CONSTANTINIDES C, CHOREMI-PAPADOPOULOU H and DIMOPOULOS C (2018) COMPARATIVE EVALUATION OF THE DIAGNOSTIC PERFORMANCE OF THE BTA STAT TEST, NMP22 AND URINARY BLADDER CANCER ANTIGEN FOR PRIMARY AND RECURRENT BLADDER TUMORSJournal of Urology, VOL. 166, NO. 2, (470-475), Online publication date: 1-Aug-2001. Volume 163Issue 6June 2000Page: 1689-1692 Advertisement Copyright & Permissions© 2000 by American Urological Association, Inc.Keywordscytologytumor markers, antigens, tumorbladderbladder neoplasmsMetricsAuthor Information MIKA-P. RAITANEN More articles by this author TIMO MARTTILA More articles by this author EERO KAASINEN More articles by this author ERKKI RINTALA More articles by this author RISTO AINE More articles by this author TEUVO L.J. TAMMELA More articles by this author TEUVO L.J. TAMMELA More articles by this author the FINNBLADDER GROUP More articles by this author Expand All Advertisement PDF downloadLoading ...