Complete Amino Acid Sequence of the B Chain of Mistletoe Lectin I
1998; Elsevier BV; Volume: 246; Issue: 3 Linguagem: Inglês
10.1006/bbrc.1998.8670
ISSN1090-2104
AutoresMontserrat Huguet Soler, Stanka Stoeva, Wolfgang Voelter,
Tópico(s)Transgenic Plants and Applications
ResumoThe primary structure of the B chain of mistletoe lectin I, the component of a commercially available extract fromViscum albumexhibiting immunomodulatory capacity, was established based on amino acid sequence analysis of the protein and peptides derived from its enzymatic digestion. It is composed of 264 residues, including seven cysteine residues and threeN-linked carbohydrate chains. The amino acid sequence of MLB shows a high homology with those from other structurally related galactoside-specific lectins such as ricin and abrin with 169 and 146 identities, respectively. These results are of crucial importance in order to understand the biological activity of ML-I.
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