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THE LIVER NEITHER PROTECTS THE KIDNEY FROM REJECTION NOR IMPROVES KIDNEY GRAFT SURVIVAL AFTER COMBINED LIVER AND KIDNEY TRANSPLANTATION FROM THE SAME DONOR1

1996; Wolters Kluwer; Volume: 61; Issue: 9 Linguagem: Inglês

10.1097/00007890-199605150-00021

1534-6080

S Katznelson, J. Michael Cecka,

Liver Disease and Transplantation

It has been proposed that the liver protects a simultaneously transplanted kidney from acute rejection. Using the United Network for Organ Sharing database, we compared the kidney allograft data from 248 combined liver and kidney transplants (LKT) with a control group comprising 206 contralateral kidney alone transplants (KAT) from the same donor. The LKT and KAT groups were identical with respect to most baseline parameters, save a greater degree of HLA matching in the KAT group. The overall 3-year graft survival rate was higher in the KAT group compared with the LKT group (80% vs 68%, P<0.01). When these data were censored to remove death as a cause of graft loss and to minimize the matching effect, the 3-year survival rates were not statistically different (78% for KAT and 81% for LKT, P=NS). We conclude that the liver neither protects the kidney from rejection nor improves kidney allograft function or survival after LKT.