Theoretical studies of the effects of heterogeneity in the parasite population on the transmission dynamics of malaria
1994; Royal Society; Volume: 256; Issue: 1347 Linguagem: Inglês
10.1098/rspb.1994.0075
ISSN1471-2954
AutoresSunetra Gupta, J. Swinton, Roy M. Anderson,
Tópico(s)Mosquito-borne diseases and control
ResumoRestricted accessMoreSectionsView PDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditEmail Cite this article Gupta Sunetra , Swinton Jonathan and Anderson Roy Malcolm 1994Theoretical studies of the effects of heterogeneity in the parasite population on the transmission dynamics of malariaProc. R. Soc. Lond. B.256231–238http://doi.org/10.1098/rspb.1994.0075SectionRestricted accessArticleTheoretical studies of the effects of heterogeneity in the parasite population on the transmission dynamics of malaria Sunetra Gupta Google Scholar Find this author on PubMed Search for more papers by this author , Jonathan Swinton Google Scholar Find this author on PubMed Search for more papers by this author and Roy Malcolm Anderson Google Scholar Find this author on PubMed Search for more papers by this author Sunetra Gupta Google Scholar Find this author on PubMed , Jonathan Swinton Google Scholar Find this author on PubMed and Roy Malcolm Anderson Google Scholar Find this author on PubMed Published:22 June 1994https://doi.org/10.1098/rspb.1994.0075AbstractPeriodicity in malaria transmission has generally been ascribed to seasonal fluctuations in mosquito population density or spatial heterogeneity with periodic migration. In this paper we demonstrate that simple models of strain heterogeneity can generate periodic behaviour as a consequence of the interaction between parasite strains and host immunological defences. As the degree of cross-immunity between strains increases, the system moves from a régime of independent strain transmission and coexistence, through increasingly coupled behaviour, to the displacement of the strain of lower transmissibility by the strain with a higher basic reproductive rate (R0). Cross-immunity thus serves both to bring the strains into competition, and also to couple the dynamics. We find analytical and numerical results on strain coexistence to show how the range of possible outcomes may be read as an effect of the tension between these two effects of cross-protection.FootnotesThis text was harvested from a scanned image of the original document using optical character recognition (OCR) software. As such, it may contain errors. 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This Issue22 June 1994Volume 256Issue 1347 Article InformationDOI:https://doi.org/10.1098/rspb.1994.0075PubMed:7914705Published by:Royal SocietyPrint ISSN:0962-8452Online ISSN:1471-2954History: Manuscript received31/01/1994Manuscript accepted03/03/1994Published online01/01/1997Published in print22/06/1994 License:Scanned images copyright © 2017, Royal Society Citations and impact Large datasets are available through Proceedings B's partnership with Dryad
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