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Prostaglandin F2α in the uterus of ewes during early pregnancy

1972; Elsevier BV; Volume: 1; Issue: 6 Linguagem: Inglês

10.1016/0090-6980(72)90017-2

1878-416X

Laird Wilson, R. L. Butcher, E. K. Inskeep,

Estrogen and related hormone effects

PGF2α has been postulated to be the uterine luteolytic factor. If this is true, then one might expect the levels of PGF2α to be lower during early pregnancy. However, in the present study levels of PGF2α were found to be significantly higher in both content (ng) and concentration (ng/gm) in the endometrium of day-13 pregnant ewes (2375, 152 respectively) compared to day-13 nonpregnant animals (1478, 89 respectively). These results imply that the luteotropic effects of the embryo must occur by some mechanism other than inhibition of production or release of the uterine luteolytic factor.