Portal de Periódicos da CAPES

Masculinizing tumor of the ovary, apparently with adrenocortical activitya histologic, ultrastructural, and biochemical study

1969; Wiley; Volume: 23; Issue: 6 Linguagem: Inglês

10.1002/1097-0142(196906)23

1097-0142

Leopold G. Koss, Edmund O. Rothschild, Martin Fleisher, John E. Francis,

Reproductive Biology and Fertility

CancerVolume 23, Issue 6 p. 1245-1258 ArticleFree Access Masculinizing tumor of the ovary, apparently with adrenocortical activity a histologic, ultrastructural, and biochemical study Dr. Leopold G. Koss MD, Dr. Leopold G. Koss MD Departments of Pathology of the Memorial Hospital for Cancer and Allied Diseases, New York, N.Y.Search for more papers by this authorDrs. Edmund O. Rothschild MD, Drs. Edmund O. Rothschild MD The Division of Pathology, Sloan-Kettering Institute for Cancer Research, New YorkSearch for more papers by this authorDr. Martin Fleisher PhD, Dr. Martin Fleisher PhD The Division of Pathology, Sloan-Kettering Institute for Cancer Research, New YorkSearch for more papers by this authorDrs. John E. Francis jr. MD, Drs. John E. Francis jr. MD The Division of Pathology, Sloan-Kettering Institute for Cancer Research, New YorkSearch for more papers by this author Dr. Leopold G. Koss MD, Dr. Leopold G. Koss MD Departments of Pathology of the Memorial Hospital for Cancer and Allied Diseases, New York, N.Y.Search for more papers by this authorDrs. Edmund O. Rothschild MD, Drs. Edmund O. Rothschild MD The Division of Pathology, Sloan-Kettering Institute for Cancer Research, New YorkSearch for more papers by this authorDr. Martin Fleisher PhD, Dr. Martin Fleisher PhD The Division of Pathology, Sloan-Kettering Institute for Cancer Research, New YorkSearch for more papers by this authorDrs. John E. Francis jr. MD, Drs. John E. Francis jr. MD The Division of Pathology, Sloan-Kettering Institute for Cancer Research, New YorkSearch for more papers by this author First published: June 1969 https://doi.org/10.1002/1097-0142(196906)23:6 3.0.CO;2-SCitations: 14AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Bauer, J., and Karl, J.: Der chemische und krystalline Nachweis von androgenen und corticoiden Wirkstoffen aus Urin und Geschwulstgewebe bei virilisierendendem Ovarial-tumor. Z. Ges. Exp. Med. 118: 425– 452, 1952. 2 Baulieu, E. E., Peillous, F., and Migeon, C. J.: Adrenogenital syndrome. In The Adrenal Cortex. A. B. Eisenstein, ed., Boston, Little, Brown & Co., 1967; pp. 553– 637. 3 Beals, T. F.. Pierce, G. B., Jr., and Schroeder, C. F.: The ultrastructure of human testicular tumors. I. Interstitial cell tumors J. Urol., 93: 64– 73, 1965. 4 Bjersing, L.: On the ultrastructure of follicles and isolated follicular granulosa cells of porcine ovary. Z. Zellforsch. 82: 173– 186, 1967. 5 Bjersing, L.: On the ultrastructure of granulosa lutein cells in porcine corpus luteum. With special reference to endoplasmic reticulum and steroid hormone synthesis. Z. Zellforsch. 82: 187– 211, 1967. 6 Blanchette, E. J.: Ovarian steroid cells. I. Differentiation of the lutein cell from the granulosa follicle cell during the preovulatory stage and under the influence of exogenous gonadotrophins. J. Cell Biol. 31: 501– 516, 1966. 7 Blanchette, E. J.: Ovarian steroid cells. II. The lutein cell. J. Cell Biol. 31: 517– 542, 1966. 8 Brenner, R. M.: Fine structure of adrenocortical cells in adult male rhesus monkeys. Amer. J. Anat. 119: 429– 453, 1966. 9 Brown, J. B., Bulbrook, R. D., and Greenwald, F. C.: An evaluation of a chemical method for the estimation of oestriol, oestrone and oestradiol-17β in human urine. J. Endocrin. 16: 4– 48, 1957. 10 Bryson, M. J., Dominguez, O. V., Kaiser, I. H., Samuels, L. T., and Sweat, M. L.: Enzymic steroid conversions in a masculinovoblastoma. J. Clin. Endocrin. 22: 773– 783, 1962. 11 Carr, I.: The ultrastructure of the human adrenal cortex before and after stimulation with ACTH. J. Path. Bact. 81: 101– 106, 1961. 12 Carr, I., and Carr, J.: Membranous whorls in the testicular intestitial cells. Anat. Rec. 144: 143– 147, 1962. 13 Carr, I. A.: The electron microscopy of the adrenal cortex. In The Human Adrenal Cortex. A. R. Currie, T. Symington and J. K. Grant, eds., Baltimore, The Williams & Wilkins Co., 1962. 14 Cervos-Navarro, J., Tonutti, E., and Bayer, J. M.: Elektronenmikroskopische Untersuchung eines androgenbildenden Leydigzelltumors. Endokrinologie 47: 23– 51, 1964. 15 Christensen, A. K.: The fine structure of testicular interstitial cells in guinea pigs. J. Cell. Biol. 26: 911– 935, 1965. 16 Christensen, A. K., and Fawcett, D. W.: The fine structure of testicular interstitial cells in mice. Amer. J. Anat. 118: 551– 572, 1966. 17 Christensen, A. K., and Fawcett, D. W.: The normal fine structure of opossum testicular interstitial cells. J. Biophys. Biochem. Cytol. 9: 653– 670, 1961. 18 Crabo, B.: Fine structure of the interstitial cells of the rabbit testes. Z. Zellforsch. 61: 587– 604, 1963. 19 Devis, R.: Méthodes chimiques et applications cliniques du fractionnement chromatographique des stéroïdes urinaires. Annales d'Endocrinologie 12: 451– 480, 1951. 20 Drekter, I. J., Heisler, A., Scism, G. R., Stern, S., Pearson, S., and McGavack, T. H.: The determination of urinary steroids. I. The preparation of pigment-free extracts and a simplified procedure for the estimation of total 17-ketosteroids. J. Clin. Endocrin. 12: 55– 65, 1952. 21 Enders, A. C.: Observations on the fine structure of lutein cells. J. Cell Biol. 12: 101– 113, 1962. 22 Enders, A. C., and Lyons, W. R.: Observations on the fine structure of lutein cells. II. The effect of hypo-physectomy and mammotrophic hormone in the rat. J. Cell Biol. 22: 127– 141, 1964. 23 Engel, L. L., Dorfman, R. I., and Abarbanel, A. R.: Neutral steroids in the urine of patients with luteoma of the ovary. J. Clin. Endocrin. 13: 903, 1953. 24 Epstein, J. A., Levinson, C. J., and Kupperman, H. S.: Ovarian adrenal rest tumor (masculinovoblastoma) simulating adrenal virilism. Amer. J. Obstet. Gynec. 74: 982, 1957. 25 Fawcett, D. W., and Burgos, M. H.: Studies on the fine structure of the mammalian testis. II. The human interstitial tissue. Amer. J. Anat. 107: 245– 269, 1960. 26 Gadd, C.-B., Hellsten, H., and Knutson, F.: Masculinovoblastoma (adrenal-like tumour). A rare virilizing ovarian tumour. Acta Obstet. Gynec. Scand. 39: 239– 258, 1960. 27 Giacomelli, F., Wiener, J., and Spiro, D.: Cytological alterations related to stimulation of the zona glomerulosa of the adrenal gland. J. Cell Biol. 26: 499– 522, 1965. 28 Green, J. A., Garcilzao, J. A., and Maqueo, M.: Ultrastructure of the human ovary. II. The luteal cell at term. Amer. J. Obstet. Gynec. 99: 855– 863, 1967. 29 Green, J. A., and Maqueo, M.: Ultrastructure of the human ovary. I. The luteal cell during the menstrual cycle. Amer. J. Obstet Gynec. 92: 946– 957, 1965. 30 Green, J. A., and Maqueo, M.: Histopathology and ultrastructure of an ovarian hilar cell tumor. Amer. J. Obstet. Gynec., 96: 478– 485, 1966. 31 Hughesdon, P. E.: Ovarian lipoid and theca cell tumors; their origins and interrelations. Obstet. Gynec. Survey 21: 245– 288, 1966. 32 Johannisson, E.: The foetal adrenal cortex in the human; its ultrastructure at different stages of development and in different functional states. Acta Endocr. (København) 130: 1– 107, 1968. 33 Karnofsky, M. J.: Simple methods for „staining with lead„ at high pH in electron microscopy. Biophys. Biochem. Cytol. 11: 729– 731, 1961. 34 Kliman, B., and Briefer, C.: The gas liquid chromatography of steroids. In Memoirs of the Society for Endocrinology, J. K. Grant, ed., No. 16, London, Cambridge University Press, 1967; pp. 229– 240. 35 Lees, D. H., and Paine, C. G.: Lipoid masculinizing tumours of the ovary. With a report of a case. J. Obstet. Cynaec. Brit. Comm. 65: 710– 717, 1958. 36 Lever, J. D.: Remarks on the electron microscopy of the rat corpus luteum and comparison with earlier observations on the adrenal cortex. Anat. Rec. 124: 111– 125, 1956. 37 Lockwood, W. R.: A reliable and easily sectioned epoxy embedding medium. Anat. Rec. 150: 129– 140, 1964. 38 Long, J. A., and Jones, A. L.: Observations on the fine structure of the adrenal cortex of man. Lab. Invest. 17: 335– 370, 1967. 39 Luse, S.: Fine structure of adrenal cortex. In The Adrenal Cortex. A. B. Eisenstein, ed., Boston, Little, Brown & Co., 1967; pp. 1– 59. 40 Lynn, J. A., Varon, H. H., Kingsley, W. B., and Martin, J. H.: Ultrastructural and biochemical studies of estrogen secretory capacity of a „nonfunctional„ ovarian neoplasm (dysgerminoma). Amer. J. Path. 51: 639– 661, 1967. 41 Mathet, P.: Les tumeurs masculinisantes de l'ovaire. Thesis. Paris: Arnette, 1956. 42 Merivale, W. H. H., and Forman, L.: A case of masculinovoblastoma. Brit. Med. J. 1: 560– 563, 1951. 43 Morris, J. M., and Scully, R. E.: Endocrine Pathology of the Ovary. St. Louis, C. V. Mosby Co., 1958. 44 Oberling, C., and Bernhard, W.: The morphology of the cancer cells. In The Cell. Specialized Cells. J. Brachet and A. E. Mirsky, eds., vol. 4, part 2. New York, Academic Press, 1961. 45 Pedersen, J., and Hamburger, C.: Virilizing Levdig cell tumour of the ovary. Report of a case with special reference to the hormone excretion. Acta Endocr. (Kobenhavn) 13: 109– 122, 1953. 46 Pedowitz, P., and Pomerance, W.: Adrenal-like tumors of the ovary. Review of the literature and report of two new cases. Obstet. Gynec. 19: 183– 194, 1962. 47 Rosner, J. M., Conte, N. F., Horita, S., and Forsham, P. H.: In vivo and in vitro production of testosterone by a lipoid ovarian tumor. Amer. J. Med. 37: 638– 642, 1964. 48 Ross, M. H., Lanman, J. T., and Lind, J.: Electron microscope observations on the endoplasmic reticulum in human fetal adrenal. J. Biophys. Biochem. Cytol. 4: 659– 662, 1958. 49 Ross, M. S.: Electron microscopy of the human foetal adrenal cortex. In The Human Adrenal Cortex. A. R. Currie, T. Symington, and J. K. Grant, eds., Baltimore, The Williams & Wilkins Co., 1962. 50 Sanborn, E., Koen, P. F., McNabb, J. D., and Moore, G.: Cytoplasmic microtubules in mammalian cells. J. Ultrastruc. Res. 11: 123– 138, 1964. 51 Sandberg, A. A., Slaunwhite, W. R., Jackson, J. E., and Frawley, T. F.: Androgen biosynthesis by ovarian lipoid cell tumor. J. Clin. Endrocin. 22: 929– 934, 1962. 52 Savard, K., Dorfman, R. I., Baggett, B., Fielding, L. L., Engel, L. L., McPherson, T., Lister, L. M., Johnson, D. S., Hamblen, E. C., and Engel, F. L.: Clinical, morphological and biochemical studies of a virilizing tumor in the testis. J. Clin. Invest. 39: 534– 553. 1960. 53 Schwarz, W., Merker, H. J.: Die Hodenzwischenzellen der Ratte nach Hypophysektomie und nach Behandlung mit Choriongonadotropin und Amphenon B. Z. Zellforsch. 65: 272– 284, 1965. 54 Scully, R. E.: Androgenic lesions of ovary. In The Ovary. H. G. Grady, and D. E. Smith, eds., International Academy of Pathology, Monograph #3. Baltimore, The Williams & Wilkins Co., 1963; pp. 143– 171. 55 Sheridan, M. N., and Belt, W. D.: Fine structure of the guinea pig adrenal cortex. Anat. Rec. 149: 73– 111, 1964. 56 Silber, R. H., and Porter, C. C.: The determination of 17, 21-dihydroxy-20-ketosteroids in urine and plasma. J. Biol. Chem. 210: 923– 932, 1954. 57 Soffer, L. J.: The laboratory diagnosis of Cushing's syndrome. Preoperative differentiation between tumorous and non-tumorous adrenal cortical hyper-function. In Hormonal Steroids. Biochemistry, Pharmocology and Therapeutics. L. Martinis, and A. Pecile, eds., vol. 2. New York, Academic Press, 1965; pp. 615– 624. 58 Stein, A. A., Patti, A. A., Frawley, T. F., and Bonanno, P.: Gas liquid chromatogrephic steroid analysis in virilism. Report of a bilateral lipoid cell tumor of the ovary. Amer. J. Obstet. Gynec. 86: 360– 366, 1963. 59 Teter, J., Nadworny, J., Zachwiej, E., and Bartoszewicz, W.: Interstitial cell tumour of ovary with virilism detected pre-operatively with the help of endocrinological methods. J. Obstet. Gynaec. Brit. Comm. 68: 451– 458, 1961. 60 Watson, M. L.: Staining of tissue sections for electron microscopy with heavy metals. J. Biophys. Biochem. Cytol. 4: 475– 478, 1958. Citing Literature Volume23, Issue6June 1969Pages 1245-1258 ReferencesRelatedInformation